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Book
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Chapter
Molecular Pathology of Urinary Bladder Tumors
The unprecedented advances in cancer genetics and genomics have transformed the clinical management of solid tumors. Molecular diagnostics are now an integral part of routine clinical management for patients w...
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Article
Correction to: Performance of novel non-invasive urine assay UroSEEK in cohorts of equivocal urine cytology
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Article
Vascular architectural patterns in clear cell renal cell carcinoma and clear cell papillary renal cell carcinoma
Renal cell carcinomas (RCC) are well-vascularized tumors. Although clear cell RCC (CCRCC) show a characteristic vascular network, some cases show overlap** features with other RCC. We aimed to evaluate vascu...
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Chapter
Pathologic Features of Invasive Penile Carcinomas and Precursor Lesions
Penile cancer is rare in the United States, but highly prevalent in South America, Africa, and some regions of Asia. Most patients present in their fifties to seventies with a mean age of 58 years. Several ris...
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Article
Rare MDM2 amplification in a fat-predominant angiomyolipoma
Angiomyolipomas (AMLs) are triphasic tumors (smooth muscle, vascular and adipocytic components) with myomelanocytic differentiation, arising most commonly in the kidneys, which can show predominant epithelioid...
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Article
Immune checkpoint status and tumor microenvironment in vulvar squamous cell carcinoma
Vulvar squamous cell carcinoma accounts for 5% of cancers of the female genital tract. Current guidelines recommend wide local excision with negative surgical margins as the standard treatment. However, the ex...
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Article
Therapeutically actionable PAK4 is amplified, overexpressed, and involved in bladder cancer progression
Muscle-invasive bladder carcinomas (MIBCs) are aggressive genitourinary malignancies. Metastatic urothelial carcinoma of the bladder is generally incurable by current chemotherapy and leads to early mortality....
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Article
Performance of novel non-invasive urine assay UroSEEK in cohorts of equivocal urine cytology
Urine cytology is an essential element of the diagnostic work up of hematuria. A significant proportion of cases continue to be placed in the “atypical” or “suspicious” categories of the Paris system for urine...
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Chapter
Genitourinary Tumors
Neoplasms of the prostate and bladder are among the most common solid tumors. Recent genomic advances have contributed to our understanding of the key driver genetic alterations in these malignancies offering ...
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Article
Immunohistochemical assessment of basal and luminal markers in non-muscle invasive urothelial carcinoma of bladder
The Cancer Genome Atlas project introduced genomic taxonomy of basal and luminal molecular subtypes in muscle invasive bladder cancer. Fewer studies have addressed the molecular classification in non-muscle in...
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Article
Insulin-like growth factor-1 receptor expression in upper tract urothelial carcinoma
Insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase receptor that plays a crucial role in cell proliferation, growth, differentiation, and apoptosis. IGF1R overexpression has been ...
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Article
Single 15-Min Protocol Yields the Same Cryoablation Size and Margin as the Conventional 10–8–10-Min Protocol: Results of Kidney and Liver Swine Experiment
The objective was to determine the ablation size of a single 15-min freeze and compare it with the conventional 10-min freeze–8-min thaw–10-min freeze protocol. Secondary objectives were to determine the ablat...
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Article
Reduced immunohistochemical PTEN staining is associated with higher progression rate and recurrence episodes in non-invasive low-grade papillary urothelial carcinoma of the bladder
Non-invasive low-grade papillary urothelial carcinoma (NILGPUC) of the bladder is regarded as a relatively indolent disease. However, its propensity for frequent recurrences constitutes a major clinical proble...
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Article
Open AccessProstaglandin receptors induce urothelial tumourigenesis as well as bladder cancer progression and cisplatin resistance presumably via modulating PTEN expression
We investigated the role of prostaglandin receptors (e.g. prostaglandin E2 receptor 2 (EP2), EP4) and the efficacy of celecoxib in urothelial tumourigenesis and cancer progression.
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Article
Spectrum of genetic mutations in de novo PUNLMP of the urinary bladder
Our group and others have previously demonstrated the presence of TERT promoter mutations (TERT-mut) in 60–80% of urothelial carcinomas and some of their histologic variants. Five other genes have been frequently...
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Article
Preparing pathology for the molecular era
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Article
Toward personalized management in bladder cancer: the promise of novel molecular taxonomy
Empowered by the recent advances in next generation sequencing and bioinformatics technology, an unprecedented wave of integrated transcriptomic and genomic studies have impacted the field of bladder cancer. T...
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Article
Open AccessAIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination
A defining hallmark of primary and metastatic cancers is the migration and invasion of malignant cells. These invasive properties involve altered dynamics of the cytoskeleton and one of its major structural co...
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Article
Strong association of insulin-like growth factor 1 receptor expression with histologic grade, subtype, and HPV status in penile squamous cell carcinomas: a tissue microarray study of 112 cases
Insulin-like growth factor-1 receptor (IGF1R) plays a key role in cell growth and transformation. It is overexpressed in several solid tumors. This study evaluates IGF1R immunoexpression in penile squamous cel...
