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Open AccessIdentification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer
Since metastatic colorectal cancer (CRC) is a leading cause of cancer-related death, therapeutic approaches overcoming primary and acquired therapy resistance are an urgent medical need. In this study, the eff...
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Article
Open AccessBcl-xL is an oncogenic driver in colorectal cancer
Colorectal cancer (CRC) is the second most common malignant neoplasia in women and men worldwide. The B-cell lymphoma 2 (Bcl-2) protein family is mainly known for its pivotal role in the regulation of the mito...