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  1. Article

    Open Access

    HA1077 displays synergistic activity with daclatasvir against hepatitis C virus and suppresses the emergence of NS5A resistance-associated substitutions in mice

    The kinase C-related kinase 2 (PRK2), which phosphorylates hepatitis C virus (HCV) RNA polymerase, is a proviral factor enhancing HCV replication. Here, we report on the in vivo anti-HCV efficacy of HA1077, which...

    Seung-Hoon Lee, Jae-Su Moon, Bo-Yeong Pak, Geon-Woo Kim, Wooseong Lee… in Scientific Reports (2018)

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  2. Article

    Open Access

    Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity

    The recognition of pathogen-derived ligands by pattern recognition receptors activates the innate immune response, but the potential interaction of quorum-sensing (QS) signaling molecules with host anti-viral ...

    Wooseong Lee, Seung-Hoon Lee, Minwoo Kim, Jae-Su Moon… in Nature Communications (2018)

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