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Article

HA1077 displays synergistic activity with daclatasvir against hepatitis C virus and suppresses the emergence of NS5A resistance-associated substitutions in mice

The kinase C-related kinase 2 (PRK2), which phosphorylates hepatitis C virus (HCV) RNA polymerase, is a proviral factor enhancing HCV replication. Here, we report on the in vivo anti-HCV efficacy of HA1077, which...

Seung-Hoon Lee, Jae-Su Moon, Bo-Yeong Pak, Geon-Woo Kim, Wooseong Lee… in Scientific Reports (2018)