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Article
Open AccessTracking single hiPSC-derived cardiomyocyte contractile function using CONTRAX an efficient pipeline for traction force measurement
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) are powerful in vitro models to study the mechanisms underlying cardiomyopathies and cardiotoxicity. Quantification of the contracti...
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Article
Open AccessTamoxifen treatment ameliorates contractile dysfunction of Duchenne muscular dystrophy stem cell-derived cardiomyocytes on bioengineered substrates
Duchenne muscular dystrophy (DMD) is a progressive genetic myopathy that leads to heart failure from dilated cardiomyopathy by early adulthood. Recent evidence suggests that tamoxifen, a selective estrogen rec...
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Article
Producing Collagen Micro-stripes with Aligned Fibers for Cell Migration Assays
The orientation of collagen fibers in native tissues plays an important role in cell signaling and mediates the progression of tumor cells in breast cancer by a contact guidance mechanism. Understanding how mi...
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Article
Open AccessReaction injection molding of hydrophilic-in-hydrophobic femtolitre-well arrays
Patterning of micro- and nanoscale topologies and surface properties of polymer devices is of particular importance for a broad range of life science applications, including cell-adhesion assays and highly sen...
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Article
Open AccessBig bottlenecks in cardiovascular tissue engineering
Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, matu...
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Article
Open AccessOff-stoichiometry improves the photostructuring of thiol–enes through diffusion-induced monomer depletion
Thiol–enes are a group of alternating copolymers with highly ordered networks and are used in a wide range of applications. Here, “click” chemistry photostructuring in off-stoichiometric thiol–enes is shown to...
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Article
Rapid mold-free manufacturing of microfluidic devices with robust and spatially directed surface modifications
A new and easy-to-use method that allows for mold-free and rapid prototy** of microfluidic devices, comprising channels, access holes, and surface-modified patterns, is presented. The innovative method is b...
