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Article
Open AccessA human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
Although 90% of children with acute lymphoblastic leukemia (ALL) are now cured, the prognosis for infant-ALL remains dismal. Infant-ALL is usually caused by a single genetic hit that arises in utero: an MLL/KMT2A
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Article
Open AccessStandardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study
Amplicon-based next-generation sequencing (NGS) of immunoglobulin (IG) and T-cell receptor (TR) gene rearrangements for clonality assessment, marker identification and quantification of minimal residual diseas...
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Article
Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR
Chimeric antigen receptor (CAR)-modified T cells targeting CD19 demonstrate unparalleled responses in relapsed/refractory acute lymphoblastic leukemia (ALL)1–5, but toxicity, including cytokine-release syndrome (...
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Article
Open AccessLong-term bat abundance in sagebrush steppe
Bats of western North America face many threats, but little is known about current population changes in these mammals. We compiled 283 surveys from 49 hibernacula over 32 years to investigate population chang...
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Article
Open AccessKiller immunoglobulin-like receptor and human leukocyte antigen-C genotypes in rheumatoid arthritis primary responders and non-responders to anti-TNF-α therapy
The identification of patients who will respond to anti-tumor necrosis factor alpha (anti-TNF-α) therapy will improve the efficacy, safety, and economic impact of these agents. We investigated whether killer c...
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Article
Destruction of Raman biosignatures by ionising radiation and the implications for life detection on Mars
Raman spectroscopy has proven to be a very effective approach for the detection of microorganisms colonising hostile environments on Earth. The ExoMars rover, due for launch in 2018, will carry a Raman laser s...
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Article
Open AccessA rare cause of a common symptom, Anakinra is effective in the urticaria of Schnitzler Syndrome: a case report
Schnitzler Syndrome is an uncommon, inflammatory condition that presents with a constellation of chronic unremitting urticaria, fever, bone pain, arthralgia or arthritis, and a monoclonal IgM gammopathy. There...
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Article
Home, School, and Community Partnerships: Integrating Issues of Race, Culture, and Social Class
The current review is an examination of home–school–community partnerships utilizing an ecological approach to understand the influences of race, culture, and social class. The ecological approach recognizes t...
