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Article
Open AccessAssessing the effect of metastasis-directed therapy in oligometastatic disease using the restricted mean survival time
Metastasis-directed therapy (MDT) with stereotactic body radiotherapy (SBRT) is emerging as an effective therapeutic option for oligometastatic disease (OMD). However, a lack of phase III data, consensus guide...
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Article
Primary cemiplimab treatment for orbital squamous cell carcinoma is effective and may alleviate the need for orbital exenteration
To evaluate the effectiveness of cemiplimab, a Programmed-cell-death-1(PD-1) protein inhibitor, for the treatment of cutaneous periocular-locally-advanced squamous-cell-carcinoma (POLA-SCC) with orbital-invasion.
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Article
Open AccessAnalysis of new treatments proposed for malignant pleural mesothelioma raises concerns about the conduction of clinical trials in oncology
In this commentary, using existing clinical trial data and FDA approvals we propose that there is currently a critical need for an appropriate balancing between the financial impact of new cancer drugs and the...
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Article
microRNA expression patterns in tumor infiltrating lymphocytes are strongly associated with response to adoptive cell transfer therapy
Adoptive cell transfer (ACT) using autologous tumor infiltrating lymphocytes (TILs) was previously shown to yield clinical response in metastatic melanoma patients as an advanced line. Unfortunately, there is ...
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Article
Open AccessOcular side effects of novel anti-cancer biological therapies
To examine the ocular side effects of selected biological anti-cancer therapies and the ocular and systemic prognosis of patients receiving them. We retrospectively reviewed all medical records of patients who...
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Article
TNFSF4 (OX40L) expression and survival in locally advanced and metastatic melanoma
Immunotherapy with checkpoint inhibitors revolutionized melanoma treatment in both the adjuvant and metastatic setting, yet not all metastatic patients respond, and metastatic disease still often recurs among ...
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Article
Establishment of adoptive cell therapy with tumor infiltrating lymphocytes for non-small cell lung cancer patients
Adoptive cell therapy (ACT) of tumor infiltration lymphocytes (TIL) yields promising clinical results in metastatic melanoma patients, who failed standard treatments. Due to the fact that metastatic lung cance...
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Article
Open AccessADAR1-mediated regulation of melanoma invasion
Melanoma cells use different migratory strategies to exit the primary tumor mass and invade surrounding and subsequently distant tissues. We reported previously that ADAR1 expression is downregulated in metast...
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Article
Adipocytes Viability After Suction-Assisted Lipoplasty: Does the Technique Matter?
Suction-assisted lipoplasty (SAL; liposuction) is an established aesthetic procedure in plastic surgery. The main parameters differentiating one method of lipoplasty from another are safety, consistency of res...
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Article
Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis
Although recent studies have shown that adenosine-to-inosine (A-to-I) RNA editing occurs in microRNAs (miRNAs), its effects on tumour growth and metastasis are not well understood. We present evidence of CREB-...
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Article
A mathematical algorithm for detection of Late-onset Sepsis in very-low birth weight infants: A preliminary diagnostic test evaluation
To study the diagnostic ability of RALIS (computerized mathematical algorithm and continuous monitoring device) to detect late onset sepsis among very low birth weight preterm neonates.
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Article
Insulin-like growth factor-binding protein-7 (IGFBP7) transcript: A-to-I editing events in normal and cancerous human keratinocytes
Non-melanoma skin cancers (NMSC) are the most common malignancies in caucasians worldwide. Insulin-like growth factor-binding protein-7 (IGFBP7) was suggested to function as a tumor suppressor gene in several can...
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Article
CXCR1 as a novel target for directing reactive T cells toward melanoma: implications for adoptive cell transfer immunotherapy
Adoptive cell transfer therapy with reactive T cells is one of the most promising immunotherapeutic modalities for metastatic melanoma patients. Homing of the transferred T cells to all tumor sites in sufficie...
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Article
Systemic dysregulation of CEACAM1 in melanoma patients
It was previously shown that CEACAM1 on melanoma cells strongly predicts poor outcome. Here, we show a statistically significant increase of serum CEACAM1 in 64 active melanoma patients, as compared to 48 pati...
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Chapter and Conference Paper
The Interactions Between Pathogens and Dendritic Cells: From Paralysis of Cells to Their Recruitment for Bacterial Colonization
The encounter between invading microorganisms and dendritic cells (DC) triggers a series of events which include uptake and degradation of the microorganism, induction of a cell maturation process, as well as ...
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Article
Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus
Human cytomegalovirus, a chief pathogen in immunocompromised people, can persist in a healthy immunocompetent host throughout life without being eliminated by the immune system. Here we show that pp65, the mai...
