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Article
Open AccessDay-care, early common infections and childhood acute leukaemia: a multicentre French case–control study
We conducted a case–control study to investigate the role of early infections in the aetiology of childhood acute leukaemias. The study included 280 incident cases (240 acute lymphoblastic leukaemia and 40 acu...
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Article
Efficacy of Amphotericin B Lipid Complex in the Treatment of Invasive Fungal Infections in Immunosuppressed Paediatric Patients
The safety and efficacy of amphotericin B lipid complex (ABLC) were evaluated in a retrospective study of 46 paediatric patients with invasive infections. The study included a large proportion of patients who...
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Chapter and Conference Paper
Acute Myeloid Leukemia (AML) in Children: Results of the French Trials
During the past ten years major progress has been made in the treatment of childhood AML with the introduction of intensified induction therapy, followed by an aggressive post induction chemotherapy or an allo...
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Article
Open AccessPrognostic study of continuous variables (white blood cell count, peripheral blast cell count, haemoglobin level, platelet count and age) in childhood acute lymphoblastic leukaemia. Analysis of a population of 1545 children treated by the French Acute Lymphoblastic Leukaemia Group (FRALLE)
Many cutpoints have been proposed to categorize continuous variables in childhood acute lymphoblastic leukaemia (white blood cell count, peripheral blast cell count, haemoglobin level, platelet count and age),...
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Article
Recommendations on the use of colony-stimulating factors in children: conclusions of a European panel
During 1996 and 1997 a panel of European haematologists, oncologists, and neonatologists developed specific paediatric guidelines for the use of colony stimulating factors based on published literature and th...
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Article
Growth hormone secretion, puberty and adult height after cranial irradiation with 18 Gy for leukaemia
The dose of prophylactic cranial irradiation given to patients for acute lymphoblastic leukaemia has been decreased from 24 to 18 Gy, but the beneficial effect of this decrease on growth is controversial.
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Article
ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) WITH TEL-AML1 FUSION RNA. CLINICAL AND BIOLOGICAL FEATURES IN 17 CHILDREN TREATED WITH A UNIQUE PROTOCOL. 140
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Chapter and Conference Paper
Prognostic Factors and Treatment in Pediatric Acute Myeloblastic Leukemia: French Trials
Acute myeloblastic leukemia (AML) accounts for less 25% of all cases of childhood leukemias. The homogeneous distribution contrasts with the well-known peak of incidence observed in acute lymphoblastic leukemi...
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Article
Induction chemotherapy followed by allogeneic bone marrow transplantation or aggressive consolidation chemotherapy in childhood acute myeloblastic leukemia: A prospective study from the French Society of Pediatric Hematology and Immunology (SHIP)
In the LAME89/91 protocol, children with acute myeloid leukemia (AML) who achieved complete remission (CR) after induction chemotherapy, were treated either with allogeneic bone marrow transplantation (BMT) if...
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Article
Responses to gonadotropin releasing hormone agonist and antagonist administration in patients with gonadotroph cell adenomas
As they are clinically silent, gonadotroph cell pituitary adenomas are usually diagnosed only when pituitary enlargement causes visual impairment or hypopituitarism. In postmenopausal women presenting with pit...
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Chapter and Conference Paper
Central Nervous System Prophylaxis with High Dose Methotrexate. A Pharmacokinetic and Clinical Study: Results of Protocol FRALLE 89
Cure of childhood acute lymphoblastic leukemia (ALL) can be achieved with increasing frequency (60–70%). Therapy to prevent CNS leukemia, so called CNS prophylaxis is an important element of the treatment of n...
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Article
Diagnosis of malignancy in thyroid nodules by factor analysis of spectral and dynamic structures: a simultaneous dual-isotope dynamic study with thallium-201 and iodine-131
The aim of this study was to identify malignant thyroid nodules using iodine-123 and thallium-201 simultaneous dynamic acquisition. The image sequences acquired were processed by factor analysis of spectral an...
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Chapter
Chronic Leukaemia
Chronic granulocytic leukaemia is the most common myeloproliferative disease in childhood, accounting for approximately 2%–5% of cases of childhood leukaemia [1]. It is questionable whether chronic lymphocytic...
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Article
Quantitative blood cultures for diagnosis and management of catheter-related sepsis in pediatric hematology and oncology patients
Paired quantitative blood cultures collected simultaneously via catheter and peripheral vein in Isolator 1.5 ml tubes, were performed in 50 febrile hematology children. Samples were taken to diagnose catheter-...
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Chapter and Conference Paper
Treatment of Acute Lymphoblastic Leukemia: Protocol Fralle 83–85
From the early 1950s to the mid-1970s all acute lymphoblastic leukemias (ALLs) in childhood were treated according to a unique protocol. It became evident that some parameters had prognostic significance: age,...
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Chapter and Conference Paper
Cytogenetic Study of 130 Childhood Acute Nonlymphocytic Leukemias
A systematic cytogenetic study was started in 1977 to investigate the incidence, types, and possible relations with prognosis of childhood acute nonlymphocytic leukemia (ANLL). We report on the findings of 130...
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Chapter
Clinical Studies with the Nal-Glu GnRH Antagonist
Because of the existence of anaphylactoid side effects following the subcutaneous (sc) injection of first generation antagonists of the [D-Arg6] class, there have been few clinical trials using GnRH antagonists i...
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Chapter and Conference Paper
Hodgkin’s Disease in Children: Adaptation of Treatment to Risk Factors
Hodgkin’s disease in children is very similar to the disease observed in adults, except for its incidence, which is approximately ten times less. Therefore it has long been considered that the considerable exp...
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Article
6 TESTICULAR IRRADIATION (TI) FOR ACUTE LYMPHOBLASTIC LEUKEMIA (ALL): LONG TERM FOLLOW-UP OF LEYDIG CELL FUNCTION AND PUBERTAL DEVELOPMENT
Leydig cell insufficiency is a frequent complication of bilateral TI with 24 gy (NEJM 1983). To describe the long term follow-up and the testosterone (T) deficiency we studied, with an interval time since TI >...
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Chapter and Conference Paper
Intermediate-Risk Childhood Acute Lymphoblastic Leukemias: Amsacrine + Cytosine Arabinoside Versus Intermediate-Dose Methotrexate for Consolidation, and 6-Mercaptopurine + Methotrexate + Vincristine Versus Monthly Pulses for Maintenance
The prognosis for childhood acute lymphoblastic leukemia improved dramatically in the late 1970s, with 50%–70% of long-term survivors being reported following multiagent chemotherapy regimens. Unfortunately, t...
