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  1. No Access

    Article

    The influence of the milieu on the rate of neutralisation of herpes simplex virus 1

    The rate of neutralisation of herpes simplex virus 1 was increased by up to more than five hundred-fold when the virus suspension and antiserum were each diluted to one hundred-fold in water instead of phospha...

    C. E. Bolt, J. A. Davies, S. Randall, G. R. B. Skinner in Archives of Virology (1998)

  2. No Access

    Article

    The efficacy and safety of Skinner herpes simplex vaccine towards modulation of herpes genitalis; report of a prospective double-blind placebo-controlled trial

    A randomised, placebo-controlled, multi-centre trial of intracellular subunit herpes simplex virus (HSV) type 1 vaccine NFU.Ac.HSV-1(S–)MRC (Skinner vaccine) was conducted at three medical centres in the United ...

    G. R. B. Skinner, M. E. Turyk, C. A. Benson… in Medical Microbiology and Immunology (1997)

  3. No Access

    Article

    Characterization and immunogenicity of a candidate subunit vaccine against varicella-zoster virus

    This study describes the properties of an inactivated subunit antigen preparation from varicella-zoster virus (VZV)-infected MRC-5 cells by treatment with detergent and formaldehyde, ultracentrifugation over s...

    J. Davies, J. A. Hallworth, P. McLeish, S. Randall… in Medical Microbiology and Immunology (1994)

  4. Article

    Report of twelve years experience in open study of Skinner herpes simplex vaccine towards prevention of herpes genitalis

    Three hundred and forty-seven subjects at risk for herpes genitalis were vaccinated with Skinner vaccine, NFUAc.HSV1.(S−MRC 5), and were followed for an average duration of 2 years representing a total consortshi...

    G. R. B. Skinner, C. Fink, J. Melling, C. Wiblin… in Medical Microbiology and Immunology (1992)

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  5. No Access

    Article

    Humoral antibody response in patients with herpes genitalis: analysis of factors influencing the pattern of disease

    An investigation was made of the diagnosis of herpes genitalis, the prediction of virus type and the likelihood and frequency of clinical and asymptomatic recurrences in relation to a history of herpes labiali...

    J. A. Hallworth, D. I. Stocker, D. Shariff… in Medical Microbiology and Immunology (1988)

  6. No Access

    Article

    Antibody reactivity with Skinner HSV vaccine

    Antibody reactivity against herpes simplex virus (HSV) was investigated in 15 subjects who received three subcutaneous immunisations with Skinner HSV vaccine. Humoral antibody responses were detected against t...

    E. M. Muniu, J. Durham, D. Shariff, C. E. Hartley… in Medical Microbiology and Immunology (1987)

  7. No Access

    Article

    Follow-up report on 50 subjects vaccinated against herpes genitalis with Skinner vaccine

    Fifty subjects at risk of herpes genitalis received 109 immunizations with Skinner herpes vaccine and were assessed after a follow-up period of 4–48 months, respresenting a total follow-up period of 694 patien...

    G. R. B. Skinner, C. G. Fink, M. Cowan, A. Buchan… in Medical Microbiology and Immunology (1987)

  8. No Access

    Article

    Augmentation of the neutralisation test for type 1 HSV: Evidence of high representation of neutralising antibody in the adult community

    Optimal neutralisation of type 1 herpes simplex virus was obtained by reacting undiluted human serum with virus for 4 h at 37°C, followed by addition of antihuman globulin for 20 min; under these conditions it...

    P. J. Holmes, J. A. Hallworth, D. I. Stocker… in Medical Microbiology and Immunology (1985)

  9. No Access

    Article

    Neutralising antibody against type 1 and type 2 herpes simplex virus in cervical mucus of women with cervical intra-epithelial neoplasia

    Patients with cervical intra-epithelial neuoplasia had significantly increased neutralising antibody activity to type 2 herpes simplex virus in the cervical mucus. While patients differed from control subjects...

    J. F. Murphy, D. F. Murphy, S. Barker, M. L. Mylotte… in Medical Microbiology and Immunology (1985)

  10. No Access

    Chapter and Conference Paper

    Subunit Vaccine Compared with Infection as Protection Against Experimental Herpes Simplex Keratitis

    Education about the adverse effects of topical steroid, together with the development of increasingly effective antiviral agents, has improved the prognosis of herpes simplex keratitis (HSK). Antivirals, howev...

    B. A. Harney, D. L. Easty, G. R. B. Skinner in Herpetic Eye Diseases (1985)

  11. No Access

    Article

    The relative infrequency and low levels of neutralising and immunoprecipitating antibody to herpes simplex viruses types 1 and 2 in patients with a history of recurrent herpes genitalis

    Twenty-seven per cent of 70 patients with a history of recurrent herpes genitalis but no concomitant history of recurrent oral or peri-genital disease, had no detectable neutralising antibody against type 1 or...

    C. B. J. Woodman, D. Stocker, D. Sugrue… in Medical Microbiology and Immunology (1983)

  12. Article

    Prepubertal vaccination of mice against experimental infection of the genital tract with type 2 herpes simplex virus

    Pre-pubertal immunisation of mice with a formalin-inactivated type 1 and 2 herpes simplex virus vaccine conferred a level of life-long protection against primary type 2 genital infection. Protection levels wer...

    G. R. B. Skinner, D. R. Williams, A. W. Moles, A. Sargent in Archives of Virology (1980)

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  13. No Access

    Article

    The preparation, efficacy and safety of ‘antigenoid’ vaccine NFU1 (S−L+) MRC toward prevention ofHerpes simplex virus infections in human subjects

    Vaccine NFU1 (S−L+) MRC was prepared by high multiplicity infection of serum-deprived human embryonic lung (MRC 5) cells with type 1Herpes simplex virus. The preparative process removed inoculum virus particles a...

    G. R. B. Skinner, A. Buchan, C. E. Hartley… in Medical Microbiology and Immunology (1980)

  14. No Access

    Article

    The effect of lithium chloride on the replication ofHerpes simplex virus

    Lithium chloride inhibited the replication of type 1 and type 2Herpes simplex virus at concentrations which permitted host cell replication. Virus polypeptide and antigen synthesis were unaffected while viral DNA...

    G. R. B. Skinner, C. Hartley, A. Buchan, L. Harper… in Medical Microbiology and Immunology (1980)

  15. Article

    Smallpox research at Birmingham

    G. R. B. SKINNER, A. BUCHAN in Nature (1979)

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  16. No Access

    Article

    Preparation and efficacy of an inactivated subunit vaccine (NFUI BHK) against type 2Herpes simplex virus infection

    A vaccine againstHerpes simplex virus infection was prepared by Nonidet NP 40 and formalin treatment of a type 1, infected-cell extract; virus particles were removed by ultracentrifugation over sucrose. These pro...

    G. R. B. Skinner, D. R. Williams, A. Buchan… in Medical Microbiology and Immunology (1978)

  17. No Access

    Article

    Prevalence of type-specific antibody against type 1 and type 2 herpes simplex virus in women with abnormal cervical cytology; evidence towards pre-pubertal vaccination of sero-negative female subjects

    Patients with abnormal cervical cytology demonstrated a higher prevalence of type-specific complement-fixing antibody to type 2 herpes simplex virus than patients with negative cervical cytology and patients w...

    G. R. B. Skinner, J. E. Whitney, C. Hartley in Archives of Virology (1977)

  18. No Access

    Article

    Detection of type-specific antibody to herpes simplex virus type 1 and 2 in human sera by complement-fixation tests

    Type-specific antigens for herpes simplex virus type 1 and 2 were prepared by rigorous absorption of cell extracts with heterotypic immune sera. Type-specificity was demonstrated by immunodiffusion and complem...

    G. R. B. Skinner, Ch. Hartley, Janet E. Whitney in Archives of Virology (1976)