31 Result(s)

Article

One cell–one antibody: prelude and aftermath

This year marks the 50th anniversary of Burnet's clonal selection theory. Here Gustav Nossal recounts his pioneering work that supported Burnet's theory and led to the death of the direct template hypothesis.

G J V Nossal in Nature Immunology (2007)

Article

A purgative mastery

G. J. V. Nossal in Nature (2001)

Chapter

Affinity Maturation of the Primary Response by V Gene Diversification

A key feature of the primary immune response to T cell-dependent antigens is the increase in the average affinity of antigen-specific antibody during the course of the response (Eisen and Siskind 1964; Siskind an...

D. M. Tarlinton, A. Light, G. J. V. Nossal… in Somatic Diversification of Immune Responses (1998)

Article

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells

GERMINAL centres are dynamic microenvironments of B-lympho-cyte differentiation, which develop in secondary lymphoid tissues during immune responses^1-3. Within germinal centres, activated B lymphocytes proliferat...

Ball Pulendran, George Kannourakis, Sara Nouri, Kenneth G. C. Smith… in Nature (1995)

Article

How to stop bad B cells

G. J. V. Nossal in Nature (1994)

Chapter and Conference Paper

Immunological Tolerance Revisited in the Molecular Era

This work was supported by the National Health and Medical Research Council, Canberra, Australia; by Grant AI-03958 from the National Institute of Allergy and Infectious Diseases, United States Public Health S...

G. J. V. Nossal, M. G. McHeyzer-Williams, B. Pulendran… in Progress in Immunology Vol. VIII (1993)

Article

Molecular characterization of single memory B cells

PRIMARY antigenic exposure results in an initial antibody response and the T cell-dependent induction of B-cell memory^1,2. Memory B-cell differentiation is characterized by somatic hypermutation in antibody varia...

Michael G. McHeyzer-Williams, G. J. V. Nossal, Paul A. Lalor in Nature (1991)

Article

Interleukins 4 and 5 control expression of IL-2 receptor on murine B cells through independent induction of its two chains

RESTING B cells express few, if any, receptors for interleukin-2 (IL-2), whereas activated B cells can express receptors for and respond to IL-2 (refs 1, 2). IL-2 receptors can exist on the cell surface in thr...

Michael S. Loughnan, G. J. V. Nossal in Nature (1989)

Chapter and Conference Paper

Functional Clonal Deletion and Suppression as Complementary Mechanisms in T Lymphocyte Tolerance

Immunology is frequently the prisoner of its own semantics. Evolution designed an immune system equipped to recognize all foreign antigens, the structure of which it cannot know in advance. The solution involv...

G. J. V. Nossal, B. L. Pike, M. F. Good… in Specificity and Function of Clonally Devel… (1986)

Article

Perspectives on the regulatory biology of the B lymphocyte

B lymphocytes with receptors specific for a particular hapten have been prepared through an antigen-affinity procedure. Methods have been developed for the clonal stimulation of these cellsin vitro, with a single...

G. J. V. Nossal in Folia Microbiologica (1985)

Chapter

World Endemic Disease

Parasitic diseases are rampant throughout the world. In 1976, according to WHO estimates, 1.2 billion people lived in areas where malaria continued to flourish despite some programs for control in areas where ...

Graham V. Brown, G. J. V. Nossal in Biomedical Institutions, Biomedical Fundin… (1983)

Chapter

Differentiation of B Cells and the Clonal Abortion Theory

During the early years of research on immunological tolerance (1), it was generally believed that induction of the phenomenon could only be achieved in embryonic or very young animals, implying a special susce...

G. J. V. Nossal in Function and Structure of the Immune System (1979)

Chapter

General Summary

How well have we fulfilled the main trends set for the conference?

G. J. V. Nossal in Function and Structure of the Immune System (1979)

Chapter

Introduction

I wish to take as a theme for my brief opening remarks the provocative title of a recent paper by Dr. H. Mayer, Director of the Bureau of Biologics of the U.S. Department of Health, Education and Welfare. He a...

G. J. V. Nossal in Function and Structure of the Immune System (1979)

Article

Growth of B lymphocyte colonies in vitro from mouse lymphoid organs

TECHNIQUES now exist for obtaining clonal growth in semi-solid agar of mouse neutrophil, macrophage, eosinophil, erythropoietic and megakaryocytic colonies^1–5. Previous attempts to obtain colony formation by mous...

D. METCALF, N. L. WARNER, G. J. V. NOSSAL, J. F. A. P. MILLER, K. SHORTMAN… in Nature (1975)

Article

Antigen-Lokalisation bei congenitaler Thymus-Aplasie

J. Mitchell, J. Pye, M. C. Holmes, G. J. V. Nossal in Colloid and Polymer Science (1974)