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Article
Open AccessThe JAK1/2 inhibitor ruxolitinib in patients with COVID-19 triggered hyperinflammation: the RuxCoFlam trial
Dysregulated hyperinflammatory response is key in the pathogenesis in patients with severe COVID-19 leading to acute respiratory distress syndrome and multiorgan failure. Whilst immunosuppression has been prov...
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Article
Klinisches Vorgehen bei intraokulären Lymphomen
Die Einteilung der intraokulären Lymphome erfolgt in uveale Lymphome mit Beteiligung der Aderhaut, des Ziliarkörpers oder der Iris und die vitreoretinalen Lymphome mit isolierter oder kombinierter Beteiligung ...
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Article
Open AccessEfficacy and safety of lipegfilgrastim versus pegfilgrastim in elderly patients with aggressive B cell non-Hodgkin lymphoma (B-NHL): results of the randomized, open-label, non-inferiority AVOID neutropenia study
Lipegfilgrastim has been shown to be non-inferior to pegfilgrastim for reduction of the duration of severe neutropenia (DSN) in breast cancer patients. This open-label, non-inferiority study assessed the effic...
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Article
High-dose chemotherapy with autologous haematopoietic stem cell support for relapsed or refractory primary CNS lymphoma: a prospective multicentre trial by the German Cooperative PCNSL study group
To investigate safety and efficacy of high-dose chemotherapy followed by autologous stem cell transplantation (HCT-ASCT) in relapsed/refractory (r/r) primary central nervous system lymphoma (PCNSL), we conduct...
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Article
High-dose thiotepa-based chemotherapy with autologous stem cell support in elderly patients with primary central nervous system lymphoma: a European retrospective study
In this retrospective multicentre study, we investigated the outcomes of elderly primary central nervous system lymphoma (PCNSL) patients (⩾65 years) who underwent high-dose chemotherapy followed by autologous...
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Article
Open AccessHigh-dose methotrexate-based immuno-chemotherapy for elderly primary CNS lymphoma patients (PRIMAIN study)
To investigate immuno-chemotherapy for elderly immuno-competent patients (⩾65 years) with newly diagnosed primary central nervous system lymphoma, we conducted a multicentre single-arm trial. One cycle consist...
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Article
Outcomes for HIV-positive patients with primary central nervous system lymphoma after high-dose chemotherapy and auto-SCT
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Article
Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma
Recent studies addressing the molecular characteristics of PCNSL, which is defined as malignant B-cell lymphoma with morphological features of DLBCL, have significantly improved our understanding of the pathog...
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Article
Therapie anterior gelegener Orbitatumoren
Die Diagnose Orbitatumor wird anhand klinischer und neuroradiologischer Kriterien gestellt und in unklaren Fällen durch eine Biopsie histologisch gesichert. Das Spektrum möglicher Diagnosen ist vielfältig. Ent...
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Chapter
Procédures thérapeutiques particulières
Les cellules souches hématopoïétiques sont une petite population essentiellement dormante de cellules indifférenciées. Elles sont caractérisées par leur capacité d’auto-renouvellement par division cellulaire c...
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Chapter
Hémopathies malignes
Déf.: Hémopathie maligne de la lignée lymphoïde avec transformation d’un précurseur lymphoblastique, arrêt de la différentiation et expansion clonale. Elle est caractérisée par la suppression de l’hé...
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Article
Zielgerichtete Therapie gastrointestinaler Tumoren
Intensive wissenschaftliche Bemühungen haben in den letzten 20 Jahren zu einem verbesserten Verständnis der Biologie von Tumorzellen geführt. So führen genetische und epigenetische Veränderungen in Tumorzellen...
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Article
Primary CNS lymphoma in immunocompetent patients from 1989 to 2001: a retrospective analysis of 164 cases uniformly diagnosed by stereotactic biopsy
Background. We present outcome data of a cohort of 164 immunocompetent PCNSL patients uniformly diagnosed at a single center for stereotactic neurosurgery, and evaluate the acceptance and impact of combination ra...
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Article
Treatment and prophylaxis of severe infections in neutropenic patients by granulocyte transfusions
Bacterial and fungal infections are the main cause of morbidity and mortality in neutropenic patients. To resolve infections, an adequate number of functional granulocytes is required. Successful treatment of...