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  1. Article

    Open Access

    The JAK1/2 inhibitor ruxolitinib in patients with COVID-19 triggered hyperinflammation: the RuxCoFlam trial

    Dysregulated hyperinflammatory response is key in the pathogenesis in patients with severe COVID-19 leading to acute respiratory distress syndrome and multiorgan failure. Whilst immunosuppression has been prov...

    J. Hammersen, S. Birndt, K. Döhner, P. Reuken, A. Stallmach, P. Sauerbrey… in Leukemia (2023)

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  2. No Access

    Article

    Klinisches Vorgehen bei intraokulären Lymphomen

    Die Einteilung der intraokulären Lymphome erfolgt in uveale Lymphome mit Beteiligung der Aderhaut, des Ziliarkörpers oder der Iris und die vitreoretinalen Lymphome mit isolierter oder kombinierter Beteiligung ...

    C. Schiemenz, S. Lüken, A. M. Klassen, M. Ranjbar, G. Illerhaus… in Die Ophthalmologie (2022)

  3. Article

    Open Access

    Efficacy and safety of lipegfilgrastim versus pegfilgrastim in elderly patients with aggressive B cell non-Hodgkin lymphoma (B-NHL): results of the randomized, open-label, non-inferiority AVOID neutropenia study

    Lipegfilgrastim has been shown to be non-inferior to pegfilgrastim for reduction of the duration of severe neutropenia (DSN) in breast cancer patients. This open-label, non-inferiority study assessed the effic...

    Hartmut Link, G. Illerhaus, U. M. Martens, A. Salar… in Supportive Care in Cancer (2021)

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  4. No Access

    Article

    High-dose chemotherapy with autologous haematopoietic stem cell support for relapsed or refractory primary CNS lymphoma: a prospective multicentre trial by the German Cooperative PCNSL study group

    To investigate safety and efficacy of high-dose chemotherapy followed by autologous stem cell transplantation (HCT-ASCT) in relapsed/refractory (r/r) primary central nervous system lymphoma (PCNSL), we conduct...

    B Kasenda, G Ihorst, R Schroers, A Korfel, I Schmidt-Wolf, G Egerer… in Leukemia (2017)

  5. No Access

    Article

    High-dose thiotepa-based chemotherapy with autologous stem cell support in elderly patients with primary central nervous system lymphoma: a European retrospective study

    In this retrospective multicentre study, we investigated the outcomes of elderly primary central nervous system lymphoma (PCNSL) patients (⩾65 years) who underwent high-dose chemotherapy followed by autologous...

    E Schorb, C P Fox, K Fritsch, L Isbell, A Neubauer… in Bone Marrow Transplantation (2017)

  6. Article

    Open Access

    High-dose methotrexate-based immuno-chemotherapy for elderly primary CNS lymphoma patients (PRIMAIN study)

    To investigate immuno-chemotherapy for elderly immuno-competent patients (⩾65 years) with newly diagnosed primary central nervous system lymphoma, we conducted a multicentre single-arm trial. One cycle consist...

    K Fritsch, B Kasenda, E Schorb, P Hau, J Bloehdorn, R Möhle, S Löw, M Binder… in Leukemia (2017)

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  7. No Access

    Article

    Outcomes for HIV-positive patients with primary central nervous system lymphoma after high-dose chemotherapy and auto-SCT

    A O'Neill, K Mikesch, K Fritsch, B Kasenda, L Banerjee… in Bone Marrow Transplantation (2015)

  8. No Access

    Article

    Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma

    Recent studies addressing the molecular characteristics of PCNSL, which is defined as malignant B-cell lymphoma with morphological features of DLBCL, have significantly improved our understanding of the pathog...

    M Deckert, A Engert, W Brück, A J M Ferreri, J Finke, G Illerhaus, W Klapper… in Leukemia (2011)

  9. No Access

    Article

    Therapie anterior gelegener Orbitatumoren

    Die Diagnose Orbitatumor wird anhand klinischer und neuroradiologischer Kriterien gestellt und in unklaren Fällen durch eine Biopsie histologisch gesichert. Das Spektrum möglicher Diagnosen ist vielfältig. Ent...

    Prof. Dr. W.A. Lagrèze, J. Rössler, G. Illerhaus, W Maier, A Grosu in Der Ophthalmologe (2011)

  10. No Access

    Chapter

    Procédures thérapeutiques particulières

    Les cellules souches hématopoïétiques sont une petite population essentiellement dormante de cellules indifférenciées. Elles sont caractérisées par leur capacité d’auto-renouvellement par division cellulaire c...

    B. Deschler, C. I. Müller, C. F. Waller… in Précis d’hématologie et d’oncologie (2011)

  11. No Access

    Chapter

    Hémopathies malignes

    Déf.: Hémopathie maligne de la lignée lymphoïde avec transformation d’un précurseur lymphoblastique, arrêt de la différentiation et expansion clonale. Elle est caractérisée par la suppression de l’hé...

    R. Wäsch, W. Digel, M. Lübbert, K. Heining-Mikesch… in Précis d’hématologie et d’oncologie (2011)

  12. No Access

    Article

    Zielgerichtete Therapie gastrointestinaler Tumoren

    Intensive wissenschaftliche Bemühungen haben in den letzten 20 Jahren zu einem verbesserten Verständnis der Biologie von Tumorzellen geführt. So führen genetische und epigenetische Veränderungen in Tumorzellen...

    S. Heeg, G. Illerhaus, Prof. Dr. O.G. Opitz in Der Gastroenterologe (2010)

  13. No Access

    Article

    Primary CNS lymphoma in immunocompetent patients from 1989 to 2001: a retrospective analysis of 164 cases uniformly diagnosed by stereotactic biopsy

    Background. We present outcome data of a cohort of 164 immunocompetent PCNSL patients uniformly diagnosed at a single center for stereotactic neurosurgery, and evaluate the acceptance and impact of combination ra...

    F. Feuerhake, C. Baumer, D. Cyron, G. Illerhaus, M. Olschewski… in Acta Neurochirurgica (2006)

  14. No Access

    Article

    Treatment and prophylaxis of severe infections in neutropenic patients by granulocyte transfusions

    Bacterial and fungal infections are the main cause of morbidity and mortality in neutropenic patients. To resolve infections, an adequate number of functional granulocytes is required. Successful treatment of...

    G. Illerhaus, K. Wirth, A. Dwenger, C. Waller, A. Garbe, V. Brass… in Annals of Hematology (2002)