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Article
The Effect of Short-Term Irrigation of TWW on the State of Soils, Groundwater and Vegetation in the Cebala Borj-Touil Area (Tunisia)
Treated wastewater (TWW) has been used for the irrigation of a plot located in the periphery of Cebala—Borj Touil (Tunisia), the largest area irrigated with TWW since 1989. Samples from wastewater, groundwater...
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Article
Prognostic factors and follow-up parameters in patients with paroxysmal nocturnal hemoglobinuria (PNH): experience of the Austrian PNH network
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disease characterized by a deregulated complement system, chronic Coombs-negative, intravascular hemolysis, and a variable clinical course with s...
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Article
Drug-induced inhibition of phosphorylation of STAT5 overrides drug resistance in neoplastic mast cells
Systemic mastocytosis (SM) is a mast cell (MC) neoplasm with complex pathology and a variable clinical course. In aggressive SM (ASM) and MC leukemia (MCL), responses to conventional drugs are poor and the pro...
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Article
Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site
The BCR/ABL1 inhibitor Nilotinib is increasingly used to treat patients with chronic myeloid leukemia (CML). Although otherwise well-tolerated, Nilotinib has been associated with the occurrence of progressive ...
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Article
Open AccessRistocetin-induced platelet aggregation for monitoring of bleeding tendency in CLL treated with ibrutinib
Bleeding because of impaired platelet function is a major side effect of the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib. We quantitatively assessed ristocetin-induced platelet aggregation (RIPA) in 64 ...
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Article
Open AccessNDEL1-PDGFRB fusion gene in a myeloid malignancy with eosinophilia associated with resistance to tyrosine kinase inhibitors
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Article
Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth
Proteomic-based drug testing is an emerging approach to establish the clinical value and anti-neoplastic potential of multikinase inhibitors. The multikinase inhibitor midostaurin (PKC412) is a promising new a...
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Article
Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia
Advanced systemic mastocytosis (SM) is a life-threatening neoplasm characterized by uncontrolled growth and accumulation of neoplastic mast cells (MCs) in various organs and a poor survival. So far, no curativ...
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Article
KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis
Although acquired mutations in KIT are commonly detected in various categories of mastocytosis, the methodologies applied to detect and quantify the mutant type and allele burden in various cells and tissues are ...
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Article
Open AccessAzithromycin suppresses CD4+ T-cell activation by direct modulation of mTOR activity
Advanced macrolides, such as azithromycin (AZM) or clarithromycin (CLM), are antibiotics with immunomodulatory properties. Here we have sought to evaluate their in vitro influence on the activation of CD4+ T-cell...
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Article
Open AccessPAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis
The transcription factor STAT5 (signal transducer and activator of transcription 5) is frequently activated in hematological malignancies and represents an essential signaling node downstream of the BCR-ABL on...
