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Open AccessCurrent status and future potential of somatic mutation testing from circulating free DNA in patients with solid tumours
Genetic alterations can determine the natural history of cancer and its treatment response. With further advances in DNA sequencing technology, multiple novel genetic alterations will be discovered which could...
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Article
Open AccessDetection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study
This study investigated the potential clinical utility of circulating free DNA (cfDNA) as a source of BRAF mutation detection in patients enrolled into a phase II study of AZD6244, a specific MEK1/2 inhibitor, in...
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Article
Open AccessIdentification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray
The identification of novel genes or groups of genes expressed in prostate cancer may allow earlier diagnosis or more accurate staging of the disease. We describe the assembly and use of a 1877-member microarr...
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Article
The detection of K-ras mutations in colorectal cancer using the amplification-refractory mutation system
A total of 301 colorectal carcinoma (CRC) archival samples were analysed using the amplification-refractory mutation system (ARMS). Each sample was examined to determine the mutation status of codons 12 and 13...
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Article
Continuous cocaine induces persisting alterations in dopamine overflow in caudate following perfusion with a D1 agonist
The present study examined whether exposure to 5 days of continuous cocaine in rats would produce any persisting alterations of the decrease in striatal dopamine (DA) overflow produced by local infusion of a D...
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Article
Autoradiographic analysis of regional alterations in brain receptors following chronic administration and withdrawal of typical and atypical neuroleptics in rats
Rats were administered haloperidol, clozapine, raclopride, or no drug for 28 days or 8 months. Following a 3 week withdrawal period, in vitro autoradiography was utilized to examine receptor binding for dopami...
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Article
Tremorous mouth movements in rats administered chronic neuroleptics
Oral movements (OMs) in rats administered chronic haloperidol (HAL) were quantified simultaneously by a human observer and via a computerized video analysis system which monitored the distance between the uppe...
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Article
The regional distribution of d-amphetamine and local glucose utilization in rat brain during continuous amphetamine administration
The distribution of radioactivity following administration of either [3H]d-amphetamine or [3H]2-deoxy-d-glucose was examined by scintillation counting of 22 microdissected brain regions from rats pretreated with ...
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Article
Stages of recovery from central norepinephrine lesions in enriched and impoverished environments: A behavioral and biochemical study
Adult rats were injected intraventricularly with 6-OHDA and allowed to recover for varying time periods in either an enriched colony environment or in isolation cages. When tested behaviorally in a novel envir...