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  1. No Access

    Article

    Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis

    Nonsense-mediated mRNA decay (NMD) is an RNA surveillance mechanism that requires upframeshift protein 1 (UPF1). This study demonstrates that human UPF1 exerts protective effects in a rat paralysis model based...

    K L Jackson, R D Dayton, E A Orchard, S Ju, D Ringe, G A Petsko, L E Maquat… in Gene Therapy (2015)

  2. No Access

    Article

    Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain

    Latrepirdine (Dimebon; dimebolin) is a neuroactive compound that was associated with enhanced cognition, neuroprotection and neurogenesis in laboratory animals, and has entered phase II clinical trials for bot...

    J W Steele, S Ju, M L Lachenmayer, J Liken, A Stock, S H Kim… in Molecular Psychiatry (2013)

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    Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

    Latrepirdine (Dimebon) is a pro-neurogenic, antihistaminic compound that has yielded mixed results in clinical trials of mild to moderate Alzheimer's disease, with a dramatically positive outcome in a Russian ...

    J W Steele, M L Lachenmayer, S Ju, A Stock, J Liken, S H Kim… in Molecular Psychiatry (2013)

  4. No Access

    Article

    Crystal structure of elastase–substrate complex at −55 °C

    The structure of a specific acyl-enzyme intermediate in the elastase-catalysed hydrolysis of N-carbobenzoxy-L-alanyl-p-nitrophenol ester has been determined by X-ray diffraction at 3.5 Å resolution. The acyl-enzy...

    T. Alber, G. A. Petsko, D. Tsernoglou in Nature (1976)

  5. No Access

    Article

    Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5Å resolution: using amino acid sequence data

    Each subunit of triose phosphate isomerase is composed of alternate segments of polypeptide chain in the α- and β-conformations that are arranged to form an inner cylinder of parallel-pleated sheet and a largely ...

    D. W. Banner, A. C. Bloomer, G. A. Petsko, D. C. Phillips, C. I. Pogson… in Nature (1975)