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Open AccessDNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood
Human height is strongly influenced by genetics but the contribution of modifiable epigenetic factors is under-explored, particularly in low and middle-income countries (LMIC). We investigate links between blo...
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Open AccessComparing BMI with skinfolds to estimate age at adiposity rebound and its associations with cardio-metabolic risk markers in adolescence
Body mass index (BMI) reaches a nadir in mid-childhood, known as the adiposity rebound (AR). Earlier AR is associated with a higher risk of cardio-vascular diseases in later life. Skinfolds, which are a more d...
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Article
Open AccessAdiposity and Cortisol Response to Stress in Indian Adolescents
We examined associations of different adiposity measures with cortisol responses during the Trier Social Stress Test for children (TSST-C).
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Developmental origins of diabetes—an Indian perspective
The developmental origins of health disease (DOHaD) hypothesis proposes that altered environmental influences (nutrition, metabolism, pollutants, stress and so on) during critical stages of fetal growth predis...
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Article
Lack of replication of association of THSD7A with obesity
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Article
Trier social stress test in Indian adolescents
To test the Trier Social Stress Test for children (TSSTC) in a cohort of Indian adolescents.
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Article
Open AccessAssociation of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians
FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, i...
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Prediction of body-fat percentage from skinfold and bio-impedance measurements in Indian school children
Few equations for calculating body-fat percentage (BF%) from field methods have been developed in South-Asian children. The objective of this study was to assess agreement between BF% derived from primary refe...
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Article
Glucose tolerance and insulin resistance in Indian children: relationship to infant feeding pattern
Our objective was to examine whether longer duration of breast-feeding and later introduction of complementary foods are associated with lower glucose concentrations and insulin resistance (IR-HOMA) in Indian ...
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Childhood cognitive ability: relationship to gestational diabetes mellitus in India
Our aim was to test the hypothesis that gestational diabetes mellitus (GDM) in mothers is associated with poorer cognitive ability in their offspring in India.
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Relationship between physical activity measured using accelerometers and energy expenditure measured using doubly labelled water in Indian children
To test the association between physical activity measured using accelerometer counts (Actigraph) and energy expenditure (EE) measured using the doubly labelled water (DLW) method in free-living children in In...
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Low plasma vitamin B12 in pregnancy is associated with gestational ‘diabesity’ and later diabetes
This study was designed to test the hypothesis that low plasma vitamin B12 concentrations combined with high folate concentrations in pregnancy are associated with a higher incidence of gestational diabetes (GDM)...
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Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variation in newborn size
Background/Objectives: Vitamin D is required for bone growth and normal insulin secretion. Maternal hypovitaminosis D may impair fetal growth and increase the risk of gestational diabetes. We have related materna...
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FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians
Variants of the FTO (fat mass and obesity associated) gene are associated with obesity and type 2 diabetes in white Europeans, but these associations are not consistent in Asians. A recent study in Asian Indian S...
