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  1. Article

    Correction: Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions

    C. -R Pradeep, A. Zeisel, W. J. Köstler, M. Lauriola, J. Jacob-Hirsch… in Oncogene (2024)

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    Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions

    The HER2/neu oncogene encodes a receptor-like tyrosine kinase whose overexpression in breast cancer predicts poor prognosis and resistance to conventional therapies. However, the mechanisms underlying aggressi...

    C-R Pradeep, A Zeisel, W J Köstler, M Lauriola, J Jacob-Hirsch, B Haibe-Kains… in Oncogene (2012)

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    Modeling ductal carcinoma in situ: a HER2–Notch3 collaboration enables luminal filling

    A large fraction of ductal carcinoma in situ (DCIS), a non-invasive precursor lesion of invasive breast cancer, overexpresses the HER2/neu oncogene. The ducts of DCIS are abnormally filled with cells that evade a...

    C-R Pradeep, W J Köstler, M Lauriola, R Z Granit, F Zhang, J Jacob-Hirsch… in Oncogene (2012)

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    Cancer cells suppress p53 in adjacent fibroblasts

    The p53 tumor suppressor serves as a crucial barrier against cancer development. In tumor cells and their progenitors, p53 suppresses cancer in a cell-autonomous manner. However, p53 also possesses non-cell-au...

    J Bar, R Feniger-Barish, N Lukashchuk, H Shaham, N Moskovits, N Goldfinger… in Oncogene (2009)

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    P53 in blind subterranean mole rats – loss-of-function versus gain-of-function activities on newly cloned Spalax target genes

    A tumor suppressor gene, p53, controls cellular responses to a variety of stress conditions, including DNA damage and hypoxia, leading to growth arrest and/or apoptosis. Recently, we demonstrated that in blind su...

    A Avivi, O Ashur-Fabian, A Joel, L Trakhtenbrot, K Adamsky, I Goldstein… in Oncogene (2007)

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    S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation

    The p53 paralogues p73, p63 and their respective truncated isoforms have been shown to be critical regulators of developmental and differentiation processes. Indeed, both p73- and p63-deficient mice exhibit se...

    E Lapi, A Iovino, G Fontemaggi, A R Soliera, S Iacovelli, A Sacchi, G Rechavi… in Oncogene (2006)

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    The UVB-induced gene expression profile of human epidermis in vivo is different from that of cultured keratinocytes

    In order to obtain a comprehensive picture of the molecular events regulating cutaneous photodamage of intact human epidermis, suction blister roofs obtained after a single dose of in vivo ultraviolet (UV)B expos...

    C D Enk, J Jacob-Hirsch, H Gal, I Verbovetski, N Amariglio, D Mevorach… in Oncogene (2006)

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    Article

    Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue

    The ATM protein kinase, functionally missing in patients with the human genetic disorder ataxia-telangiectasia, is a master regulator of the cellular network induced by DNA double-strand breaks. The ATM gene is a...

    S Rashi-Elkeles, R Elkon, N Weizman, C Linhart, N Amariglio, G Sternberg… in Oncogene (2006)