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  1. Article

    Open Access

    Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity

    Interhemispheric axons of the corpus callosum (CC) facilitate the higher order functions of the cerebral cortex. According to current views, callosal and non-callosal fates are determined early after a neuron’...

    N. S. De León Reyes, S. Mederos, I. Varela, L. A. Weiss, G. Perea… in Nature Communications (2019)

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  2. Article

    Open Access

    Cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons

    Cell cycle reentry followed by neuronal hyperploidy and synaptic failure are two early hallmarks of Alzheimer’s disease (AD), however their functional connection remains unexplored. To address this question, w...

    E. Barrio-Alonso, A. Hernández-Vivanco, C. C. Walton, G. Perea… in Scientific Reports (2018)

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  3. Article

    Open Access

    Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer’s disease

    Given the implication of histone acetylation in memory processes, histone deacetylase inhibitors (HDACIs) have been postulated as potential modulators of cognitive impairment in Alzheimer’s disease (AD). Howev...

    M. Cuadrado-Tejedor, C. Garcia-Barroso, J. Sanzhez-Arias… in Clinical Epigenetics (2015)

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  4. No Access

    Article

    Prognostic value of minimal residual disease (MRD) in acute myeloid leukemia (AML) with favorable cytogenetics [t(8;21) and inv(16)]

    Most patients with acute myeloid leukemia (AML) and t(8;21) or inv(16) have a good prognosis with current anthracycline- and cytarabine-based protocols. Tandem analysis with flow cytometry (FC) and real-time R...

    G Perea, A Lasa, A Aventín, A Domingo, N Villamor, M Paz Queipo de Llano… in Leukemia (2006)

  5. No Access

    Article

    Synaptic regulation of the astrocyte calcium signal

    During the last years, a great amount of evidence demonstrates the existence of bidirectional communication between astrocytes and neurons, which has revealed an important active role of astrocytes in the phys...

    G. Perea, A. Araque in Journal of Neural Transmission (2005)

  6. No Access

    Article

    Loss of heterozygosity of the polymorphic PIG3 microsatellite with low frequency in de novo acute myeloid leukemias

    J F Nomdedéu, G Perea, C Estivill, A Lasa, S Brunet, A Aventín, J Sierra in Leukemia (2004)

  7. No Access

    Article

    Enhanced risk of thrombotic disease in patients with acquired vitamin B12 and/or folate deficiency: role of hyperhomocysteinemia

    A number of studies have identified elevated levels of homocysteine (Hcy) as a risk factor for thrombosis. Given the relationship between Hcy and thrombosis, a high prevalence of thrombosis would be expected ...

    A. Remacha, J. Souto, E. Rámila, G. Perea, M. Sarda, J. Fontcuberta in Annals of Hematology (2002)

  8. No Access

    Article

    Predictive factors for a successful mobilization of peripheral blood CD34+ cells in multiple myeloma

    We analyzed the prognostic factors for a successful mobilization and peripheral blood stem cell collection in a series of 57 consecutive patients with multiple myeloma (MM); a new scoring system to predict an...

    G. Perea, A. Sureda, R. Martino, A. Altés, C. Martínez, E. Cabezudo… in Annals of Hematology (2001)

  9. No Access

    Article

    Mobilization kinetics of peripheral blood progenitor cells after IAPVP-16 salvage chemotherapy plus G-CSF in lymphoproliferative disorders

    We have explored the efficacy of salvage chemotherapy combination, IAPVP-16 (ifosfamide 5 g/m2 on day 1; VP-16 100 mg/m2 on days 1–3; ara-C 1.2 g/m2/12 h on days 1 and 2; methylprednisolone 80 mg/m2 on days 1–5) ...

    A Altés, R López, R Martino, C Martinez, E Cabezudo, L Muñoz… in Bone Marrow Transplantation (2000)