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Article
Open AccessA chicken DNA methylation clock for the prediction of broiler health
The domestic chicken (Gallus gallus domesticus) is the globally most important source of commercially produced meat. While genetic approaches have played an important role in the development of chicken stocks, li...
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Article
Open AccessEpigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from aff...
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Article
Open AccessSingle-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming
Fibroblasts are an essential cell population for human skin architecture and function. While fibroblast heterogeneity is well established, this phenomenon has not been analyzed systematically yet. We have used...
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Article
The microbiota programs DNA methylation to control intestinal homeostasis and inflammation
Although much research has been done on the diversity of the gut microbiome, little is known about how it influences intestinal homeostasis under normal and pathogenic conditions. Epigenetic mechanisms have re...
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Article
Open AccessDnmt1 has an essential function despite the absence of CpG DNA methylation in the red flour beetle Tribolium castaneum
Epigenetic mechanisms, such as CpG DNA methylation enable phenotypic plasticity and rapid adaptation to changing environments. CpG DNA methylation is established by DNA methyltransferases (DNMTs), which are we...
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Open AccessThe methylome of the marbled crayfish links gene body methylation to stable expression of poorly accessible genes
The parthenogenetic marbled crayfish (Procambarus virginalis) is a novel species that has rapidly invaded and colonized various different habitats. Adaptation to different environments appears to be independent o...
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Article
Open AccessMethylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and usually progresses from a UV-induced precancerous lesion termed actinic keratosis (AK). Despite various efforts to characteriz...
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Article
Correction: Corrigendum: The zebrafish reference genome sequence and its relationship to the human genome
Nature 496, 498–503 (2013); doi:10.1038/nature12111 In this Letter, five authors were inadvertently omitted: Sharmin Begum and Christine Lloyd from the Wellcome Trust Sanger Institute, and Christa Lanz, Günter...
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Article
Open AccessAging is associated with highly defined epigenetic changes in the human epidermis
Altered DNA methylation patterns represent an attractive mechanism for understanding the phenotypic changes associated with human aging. Several studies have described global and complex age-related methylatio...
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Article
Open AccessThe zebrafish reference genome sequence and its relationship to the human genome
A high-quality sequence assembly of the zebrafish genome reveals the largest gene set of any vertebrate and provides information on key genomic features, and comparison to the human reference genome shows that...
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Article
Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster
Differentiation is accompanied by extensive epigenomic reprogramming, leading to the repression of stemness factors and the transcriptional maintenance of activated lineage-specific genes. Here we use the mamm...
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Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors
The bacterial genus Bartonella comprises 21 pathogens causing characteristic intraerythrocytic infections. Bartonella bacilliformis is a severe pathogen representing an ancestral lineage, whereas the other specie...
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Article
Open AccessGenome-wide analysis of growth phase-dependent translational and transcriptional regulation in halophilic archaea
Differential expression of genes can be regulated on many different levels. Most global studies of gene regulation concentrate on transcript level regulation, and very few global analyses of differential trans...
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Article
Open AccessComplete genome sequence of the myxobacterium Sorangium cellulosum
The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sor...
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Article
A Tetrameric Model of the Dihydrolipoamide Dehydrogenase Component of the Pyruvate Dehydrogenase Complex: Construction and Evaluation by Molecular Modeling Techniques
On the basis of the homodimeric X-ray structure of dihydrolipoamide dehydrogenase from Azotobacter vinelandii we demonstrate by protein modeling techniques that two dimeric units of this enzyme can associate to a...
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Article
Molecular Modeling Study on Dapsone and Sulfonamides Comparing Structures and Properties with Respect to Anti-Leprosy Activity
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Homology Modelling of a Newly Discovered Thioredoxin Protein and Analysis of the Force Field and Electrostatic Properties
Thioredoxin is a small protein (Mr approximately 12,000) found in all living cells from archaebacteria to humans. The active site is highly conserved and has two redox-active cysteine residues in the sequence:...
