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Chapter
Consistent and Quality-Aware Service Composition in Smart Cities
In this chapter, we review our research for dependable service composition for smart cities in both cyber and physical spaces. For the cyber space, given the active investigation on web services or web APIs, w...
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Article
Open AccessAuthor Correction: The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction
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Article
Open AccessThe interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction
Some interferon stimulated genes (ISGs) encode proteins that inhibit LINE-1 (L1) retrotransposition. Here, we use immunoprecipitation followed by liquid chromatography-tandem mass spectrometry to identify prot...
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Chapter and Conference Paper
Formal Modelling of Safety Architecture for Responsibility-Aware Autonomous Vehicle via Event-B Refinement
Ensuring the safety of autonomous vehicles (AVs) is the key requisite for their acceptance in society. This complexity is the core challenge in formally proving their safety conditions with AI-based black-box ...
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Chapter and Conference Paper
Towards Requirements Engineering for Digital Twins of Cyber-Physical Systems
Digital twins (DTs) are promising to revolutionize the way future Cyber-Physical Systems (CPSs) – which are becoming increasingly complex every day– will be developed and operated. To deal with such increasing...
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Chapter
To G0 or Not to G0: Cell Cycle Paradox in Senescence and Brain Aging
Organisms can cope with ever-changing environments by inducing various adaptive responses that increase fitness. is a stress-activated program characterized by the irreversible arrest of the in damaged, pr...
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Article
Open AccessA refinement-based development of a distributed signalling system
The decentralised railway signalling systems have a potential to increase capacity, availability and reduce maintenance costs of railway networks. However, given the safety-critical nature of railway signallin...
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Chapter and Conference Paper
Experimental Conformance Evaluation onUBER ATG Safety Case Framework withANSI/UL 4600
The safety of Self-Driving Vehicles (SDVs) is crucial for social acceptance of self-driving technology/vehicles, and how to assure such safety is of great concern for automakers and regulatory and standardizat...
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Chapter and Conference Paper
Robustifying Controller Specifications of Cyber-Physical Systems Against Perceptual Uncertainty
Formal reasoning on the safety of controller systems interacting with plants is complex because developers need to specify behavior while taking into account perceptual uncertainty. To address this, we propose...
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Chapter and Conference Paper
Architecture-Guided Test Resource Allocation via Logic
We introduce a new logic named Quantitative Confidence Logic (QCL) that quantifies the level of confidence one has in the conclusion of a proof. By translating a fault tree representing a system’s architecture...
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Chapter
Explicit Exploration of Refinement Design in Proof-Based Approach: Refinement Engineering in Event-B
Control of abstraction levels is key to tackling the increasing complexity of emerging systems such as cyber-physical systems. Formal methods for dependability assurance have been used to explore this point by...
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Article
Editorial to the theme section on model-based engineering of smart systems
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Chapter and Conference Paper
Embedding Approximation in Event-B: Safe Hybrid System Design Using Proof and Refinement
Hybrid systems consist of a discrete part (controller) that interacts with a continuous physical part (plant). Formal verification of such systems is complex and challenging in order to handle both the discret...
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Chapter and Conference Paper
Formal Distributed Protocol Development for Reservation of Railway Sections
The decentralisation of railway signalling systems has the potential to increase railway network capacity, availability and reduce maintenance costs. Given the safety-critical nature of railway signalling and ...
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Article
Consistency-preserving refactoring of refinement structures in Event-B models
Event-B has been attracting much interest because it supports a flexible refinement mechanism that reduces the complexity of constructing and verifying models of complicated target systems by taking into accou...
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Chapter and Conference Paper
Tackling Uncertainty in Safety Assurance for Machine Learning: Continuous Argument Engineering with Attributed Tests
There are unique kinds of uncertainty in implementations constructe...
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Article
Open AccessTime-Series Analysis of Tumorigenesis in a Murine Skin Carcinogenesis Model
Recent years have witnessed substantial progress in understanding tumor heterogeneity and the process of tumor progression; however, the entire process of the transition of tumors from a benign to metastatic s...
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Chapter and Conference Paper
Concepts in Quality Assessment for Machine Learning - From Test Data to Arguments
There have been active efforts to use machine learning (ML) techniques for the development of smart systems, e.g., driving support systems with image recognition. However, the behavior of ML components, e.g., ...
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Chapter and Conference Paper
Continuous Argument Engineering: Tackling Uncertainty in Machine Learning Based Systems
Components or systems implemented by using machine learning techniques have intrinsic difficulties caused by uncertainty. Specifically, it is impossible to logically or deductively conclude what they can(not) ...
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Chapter and Conference Paper
Analysis on Strategies of Superposition Refinement of Event-B Specifications
The superposition refinement with the Event-B modeling method is useful because it supports construction of models in multiple abstraction levels, and thus mitigates the burden of constructing rigorous models....
