Raynaud’s Phenomenon
From Pathogenesis to Management
Page
%P
-
Chapter
Managing the Ischemic Finger in Scleroderma
The patient is a 48-year-old Caucasian woman with limited scleroderma. The features of her disease include stiff puffy fingers, gastrointestinal reflux disease (GERD), severe Raynaud’s phenomenon (RP), and sic...
-
Book
-
Chapter
Drug Therapy
Raynaud’s phenomenon (RP) may warrant pharmacological treatment if there are significant symptoms not controlled by nonpharmacological treatment or complications. The principles of RP treatment are to decrease...
-
Chapter
Practical Approaches to Treatment: Case Studies
This Chapter presents several clinical situations to illustrate the approach to the management of Raynaud’s phenomenon and its complications. The management of several cases of scleroderma with recurrent epis...
-
Chapter
Overlooked Manifestations
Systemic sclerosis (SSc) is a heterogeneous disease with well-described traditional clinical manifestations, such as Raynaud’s phenomenon, dermal sclerosis, esophageal dysmotility, calcinosis, and telangiectas...
-
Article
Assessment of right ventricular reserve utilizing exercise provocation in systemic sclerosis
Right ventricular (RV) capacity to adapt to increased afterload is the main determinant of outcome in pulmonary hypertension, a common morbidity seen in systemic sclerosis (SSc). We hypothesized that supine bi...
-
Article
Open AccessLinaclotide for the treatment of refractory lower bowel manifestations of systemic sclerosis
Lower gastrointestinal (GI) tract involvement can affect up to 50% of systemic sclerosis (SSc) patients, and may result in malabsorption, pseudo-obstruction, hospitalization, and death. We report our experienc...
-
Article
Vascular biomarkers and digital ulcerations in systemic sclerosis: results from a randomized controlled trial of oral treprostinil (DISTOL-1)
Although there is abundant evidence of vascular perturbation from studies of peripheral blood in systemic sclerosis (SSc), there are few data about the ability to use biomarkers of vascular injury and growth f...
-
Article
Vascular complications in systemic sclerosis: a prospective cohort study
Two major complications in scleroderma patients that cause substantial morbidity and mortality are ischemic digital lesions (DL) and pulmonary hypertension (PH). The clinician’s ability to predict which patien...
-
Book
-
Article
Open AccessFrequency of circulating topoisomerase-I-specific CD4 T cells predicts presence and progression of interstitial lung disease in scleroderma
Scleroderma is an antigen-driven T cell-mediated autoimmune disease. Presence of anti-topoisomerase-I antibodies is associated with pulmonary fibrosis and predicts increased mortality. Characterization of auto...
-
Article
Open AccessGenetic susceptibility loci of idiopathic interstitial pneumonia do not represent risk for systemic sclerosis: a case control study in Caucasian patients
Systemic sclerosis (SSc)-related interstitial lung disease (ILD) has phenotypic similarities to lung involvement in idiopathic interstitial pneumonia (IIP). We aimed to assess whether genetic susceptibility lo...
-
Article
Open AccessBiomarkers of pulmonary hypertension in patients with scleroderma: a case–control study
Significant pulmonary vascular disease is a leading cause of death in patients with scleroderma, and early detection and early medical intervention are important, as they may delay disease progression and impr...
-
Book
-
Chapter
Ischemic Digital Ulcers
Systemic sclerosis (scleroderma) is unique among the rheumatic diseases because a widespread obliterative vasculopathy exists involving the peripheral arteries and microcirculation. Various forms of digital ul...
-
Article
Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma
Failure of integrin-mediated cell-matrix attachment is sufficient to initiate dermal fibrosis and autoimmunity in mouse models of scleroderma; integrin-modulating therapies prevent the recruitment and activati...
-
Book
-
Chapter
Raynaud’s Phenomenon and Sjögren’s Syndrome
In 1862, Maurice Raynaud published his medical school thesis in which he argued that some people have transient digital ischemia when exposed to cold temperatures. It is now recognized that skin blood flow in ...
-
Article
Correction: Corrigendum: Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
Nat. Genet. 42, 426–429 (2010); published online 11 April 2010; corrected after print 23 March 2011 In the version of this article initially published, incorrect affiliations were published for Lorenzo Beretta...
-
Chapter
Painful Digital Ulcers in a Scleroderma Patient with Raynaud’s Phenomenon
Raynaud’s phenomenon (RP) is seen in over 95% of patients with SSc and is often the first symptom of the disease. Scleroderma vascular disease is secondary to an obliterative vasculopathy causing not only vaso...
