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Article
Open AccessPlasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodies
Increasing evidence supports the use of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation for diagnosis of dementia. However, their performance for positive and differential diagnosis...
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Article
Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer’s disease
Dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) are often associated with depressive symptoms from the prodromal stage. The aim of the present study was to investigate the neuroanatomical correlat...
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Article
Open AccessWho am I with my Lewy bodies? The insula as a core region of the self-concept networks
Dementia with Lewy bodies (DLB) is characterized by insular atrophy, which occurs at the early stage of the disease. Damage to the insula has been associated with disorders reflecting impairments of the most f...
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Article
Open AccessGrey matter networks in women and men with dementia with Lewy bodies
Sex differences permeate many aspects of dementia with Lewy bodies (DLB), yet sex differences in patterns of neurodegeneration in DLB remain largely unexplored. Here, we test whether grey matter networks diffe...
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Article
Involvement of ApoE4 in dementia with Lewy bodies in the prodromal and demented stages: evaluation of the Strasbourg cohort
ApoE4 as a risk factor for dementia with Lewy bodies (DLB) is still an issue. We sought to determine the involvement of ApoE4 according to different clinical parameters in our cohort of patients from Strasbourg, ...
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Article
Open AccessPrevalence of iron deficiency in patients admitted to a geriatric unit: a multicenter cross-sectional study
Iron deficiency (ID) is often associated with other comorbidities in older patients and is a factor of morbimortality. However, the prevalence of ID remains poorly documented in this population.
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Open AccessImmunotherapies Targeting Amyloid and Tau Protein in Alzheimer’s Disease: Should We Move Away from Diseases and Focus on Biological Targets? A Systematic Review and Expert Opinion
Alzheimer’s disease (AD) is the most common cause of dementia worldwide, making it a major public health issue. Anti-amyloid and anti-tau antibodies are the most advanced therapeutic approach at present. Three...
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Article
Rheology of non-Brownian suspensions: a rough contact story
This paper presents a compilation of experimental and numerical results that both show that particles in a suspension under shear flow come into contact through surface roughness. Accounting for those friction...
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Article
Transient epileptic amnesia: a retrospective cohort study of 127 cases, including CSF amyloid and tau features
Transient epileptic amnesia (TEA) is a late-onset epilepsy syndrome encompassing transient iterative amnesias and interictal cognitive impairment, two features that overlap with incipient neurodegenerative dem...
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Article
Open AccessMRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies
Dementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different subtypes. We used data-driven analysis of magnetic resonance ima...
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Article
Open AccessA database of experimentally measured lithium solid electrolyte conductivities evaluated with machine learning
The application of machine learning models to predict material properties is determined by the availability of high-quality data. We present an expert-curated dataset of lithium ion conductors and associated l...
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Article
Open AccessProdromal characteristics of dementia with Lewy bodies: baseline results of the MEMENTO memory clinics nationwide cohort
Isolated subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) are the prodromal phases of dementia with Lewy bodies (DLB). MEMENTO is a nationwide study of patients with SCI and MCI with c...
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Open AccessParsing heterogeneity within dementia with Lewy bodies using clustering of biological, clinical, and demographic data
Dementia with Lewy bodies (DLB) includes various core clinical features that result in different phenotypes. In addition, Alzheimer’s disease (AD) and cerebrovascular pathologies are common in DLB. All this in...
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Article
Open AccessEmotional experience is increased and emotion recognition decreased in multiple sclerosis
Emotional disorders in multiple sclerosis (MS) are frequently described as difficulties in recognizing facial expressions, rarely in the experience dimension. Moreover, interaction between emotional disorders ...
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Article
The hippocampal region is necessary for text comprehension and memorization: a combined VBM/DTI study in neuropsychological patients
According to the Construction-Integration model (Kintsch 1988; Kintsch 1998), two forms of representation are activated during the reading and the comprehension of a text: 1) the text base, which includes semanti...
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Article
Therapeutic prevention of COVID-19 in elderly: a case–control study
COVID-19 is a particularly aggressive disease for the elderly as 86% of deaths related to COVID-19 occur in people over 65 years of age. Despite the urgent need for a preventive treatment, there are currently...
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Article
Open AccessElement selection for crystalline inorganic solid discovery guided by unsupervised machine learning of experimentally explored chemistry
The selection of the elements to combine delimits the possible outcomes of synthetic chemistry because it determines the range of compositions and structures, and thus properties, that can arise. For example, ...
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Article
Melting of hybrid organic–inorganic perovskites
Several organic–inorganic hybrid materials from the metal–organic framework (MOF) family have been shown to form stable liquids at high temperatures. Quenching then results in the formation of melt-quenched MO...
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Article
Open AccessDifferential diagnostic value of total alpha-synuclein assay in the cerebrospinal fluid between Alzheimer’s disease and dementia with Lewy bodies from the prodromal stage
Several studies have investigated the value of alpha-synuclein assay in the cerebrospinal fluid (CSF) of Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) patients in the differential diagnosis of t...
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Article
Open AccessThe insula, a grey matter of tastes: a volumetric MRI study in dementia with Lewy bodies
Despite the growing number of discoveries during the past decades about its functions, the insula remains a mysterious ‘island’. In addition to its involvement in basic functions such as gustation and interoce...
