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Protocol
The Single-Cell Gel Electrophoresis Genotoxin Sensitivity Assay
The single-cell gel electrophoresis-based genotoxin sensitivity assay (GSA) is an ex vivo approach which enables to study the impact of a variety of dietary factors, occupational exposures, and diseases on the...
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Article
Open AccessLow doses of widely consumed cannabinoids (cannabidiol and cannabidivarin) cause DNA damage and chromosomal aberrations in human-derived cells
Cannabidiol (CBD) and cannabidivarin (CBDV) are natural cannabinoids which are consumed in increasing amounts worldwide in cannabis extracts, as they prevent epilepsy, anxiety, and seizures. It was claimed tha...
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Article
Open AccessUse of HuH6 and other human-derived hepatoma lines for the detection of genotoxins: a new hope for laboratory animals?
Cell lines which are currently used in genotoxicity tests lack enzymes which activate/detoxify mutagens. Therefore, rodent-derived liver preparations are used which reflect their metabolism in humans only part...
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Article
Open AccessGenotoxic properties of XLR-11, a widely consumed synthetic cannabinoid, and of the benzoyl indole RCS-4
Aim of this study was the investigation of the genotoxic properties of XLR-11 [1-(5-fluoropentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone, a widely consumed synthetic cannabinoid (SC), and of the...
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Article
Impact of a synthetic cannabinoid (CP-47,497-C8) on protein expression in human cells: evidence for induction of inflammation and DNA damage
Synthetic cannabinoids (SCs) are marketed worldwide as legal surrogates for marihuana. In order to predict potential health effects in consumers and to elucidate the underlying mechanisms of action, we investi...
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Article
Prevention of oxidative DNA damage in inner organs and lymphocytes of rats by green tea extract
Consumption of green tea (GT) is associated with decreased incidences of specific forms of cancer in humans and it was postulated that its antioxidant (AO) properties may account for these effects. The evidenc...
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Article
Open AccessAntioxidant and free radical scavenging activities of sumac (Rhus coriaria) and identification of gallic acid as its active principle
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Article
Open AccessHospital waste water: health risk for human and environment by cytostatic drug emissions? Part I: Model calculation and chemical monitoring
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Article
Open AccessInvestigation of genotoxic effects of inhalative occupational exposure to vanadium: results of a multiple endpoint study
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Article
Open AccessHospital waste water: health risk for human and environment by cytostatic drug emissions? Part II: Biological monitoring (genotoxicity assays) and risk assessment
