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  1. No Access

    Article

    CDKI-73: an orally bioavailable and highly efficacious CDK9 inhibitor against acute myeloid leukemia

    Acute myeloid leukemia (AML) is the most common form of acute leukemia with dismal long-term prognosis with age. The most aggressive subtype of AML is MLL-AML that is characterized by translocations of the mix...

    Muhammed H. Rahaman, Yingyi Yu, Long** Zhong, Julian Adams… in Investigational New Drugs (2019)

  2. No Access

    Article

    ZJU-6, a novel derivative of Erianin, shows potent anti-tubulin polymerisation and anti-angiogenic activities

    ZJU-6 was designed to enhance anti-angiogenesis and anti-tumour activity of its parent compound Erianin, a clinic anti-tumour agent. This study investigated the detailed biological mechanism of ZJU-6 in compar...

    Frankie Lam, Tracey D. Bradshaw, Hui Mao, Scott Roberts… in Investigational New Drugs (2012)

  3. No Access

    Article

    In vitro antitumor mechanism of a novel cyclin-dependent kinase inhibitor CDKI-83

    Cancer is regarded as a proliferative disorder. Inhibition of cyclin-dependent kinases (CDKs), which are the key regulators of the cell-cycle and RNA transcription, represents an attractive strategy for cancer...

    **angrui Liu, Frankie Lam, Shenhua Shi, Peter M. Fischer… in Investigational New Drugs (2012)