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  1. Article

    Open Access

    High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology

    Bcl-2 promotes cell survival by inhibiting adapters needed for the activation and cleavage of caspases thus blocking the proteolytic cascade that ultimately dismantles the cell. Bcl-2 has been investigated as ...

    Valsamo K Anagnostou, Frank J Lowery, Vassiliki Zolota, Vassiliki Tzelepi… in BMC Cancer (2010)

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  2. No Access

    Article

    Growth factor signaling in metastasis: current understanding and future opportunities

    Paget’s “seed and soil” hypothesis stated that cancer metastasis requires permissive interactions between tumor cells and secondary organ microenvironments. Many of these “permissive interactions” are now know...

    Frank J. Lowery, Dihua Yu in Cancer and Metastasis Reviews (2012)

  3. No Access

    Article

    Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

    Expression of the tumour suppressor PTEN in disseminated primary tumour cells is lost after tumour cells metastasize to the brain, with downregulation instigated by microRNAs from astrocytes, which are transfe...

    Lin Zhang, Siyuan Zhang, Jun Yao, Frank J. Lowery, Qingling Zhang… in Nature (2015)

  4. No Access

    Article

    Adoptive transfer of personalized neoantigen-reactive TCR-transduced T cells in metastatic colorectal cancer: phase 2 trial interim results

    Adoptive cell transfer (ACT) with neoantigen-reactive T lymphocytes can mediate cancer regression. Here we isolated unique, personalized, neoantigen-reactive T cell receptors (TCRs) from tumor-infiltrating lym...

    Maria Parkhurst, Stephanie L. Goff, Frank J. Lowery, Rachel K. Beyer… in Nature Medicine (2024)