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Frank J. Lowery
Oncology
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Article
Growth factor signaling in metastasis: current understanding and future opportunities
Paget’s “seed and soil” hypothesis stated that cancer metastasis requires permissive interactions between tumor cells and secondary organ microenvironments. Many of these “permissive interactions” are now know...
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Article
Open AccessHigh expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology
Bcl-2 promotes cell survival by inhibiting adapters needed for the activation and cleavage of caspases thus blocking the proteolytic cascade that ultimately dismantles the cell. Bcl-2 has been investigated as ...
