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Article
Open AccessSystematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGS
Gene fusions are important cancer drivers in pediatric cancer and their accurate detection is essential for diagnosis and treatment. Clinical decision-making requires high confidence and precision of detection...
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Article
Open AccessIdentification and characterization of relapse-initiating cells in MLL-rearranged infant ALL by single-cell transcriptomics
Infants with MLL-rearranged infant acute lymphoblastic leukemia (MLL-r iALL) undergo intense therapy to counter a highly aggressive malignancy with survival rates of only 30–40%. The majority of patients initiall...
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Article
An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas
Metastasis is the process by which cancers spread to distinct sites in the body. It is the principal cause of death in individuals suffering from cancer. For some types of cancer, early detection of metastasis...
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Article
Minimum information about a microarray experiment (MIAME)—toward standards for microarray data
Microarray analysis has become a widely used tool for the generation of gene expression data on a genomic scale. Although many significant results have been derived from microarray studies, one limitation has ...
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Article
Functional redundancy of two transcriptional coactivator complexes
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Article
Combinatorial negative regulation of glucose-responsive genes in yeast