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  1. No Access

    Article

    Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity

    Individual prefrontal cortex neurons can exhibit persistent activity during a delay between a cue and a behavioral response. Here the authors report on an mGluR5-mediated depolarization that underlies persiste...

    Kyriaki Sidiropoulou, Fang-Min Lu, Melissa A Fowler, Rui **ao… in Nature Neuroscience (2009)

  2. No Access

    Article

    The vicious cyclin of addiction

    Drug addiction is a major therapeutic challenge, as little is known about the changes in neural function that occur during its development. DNA microarray analysis has revealed a new component in the dopamine-...

    Francis J. White, Donald C. Cooper in Nature Medicine (2001)

  3. No Access

    Article

    Loss of autoreceptor functions in mice lacking the dopamine transporter

    Autoreceptors provide an important inhibitory feedback mechanism for dopamine neurons by altering neuronal functions in response to changes in extracellular levels of dopamine. Elevated dopamine may be a compo...

    Sara R. Jones, Raul R. Gainetdinov, **u-Ti Hu, Donald C. Cooper… in Nature Neuroscience (1999)

  4. No Access

    Article

    Nicotine addiction and the lure of reward

    Withdrawal from chronic nicotine exposure decreases the activity of the brain reward pathway in a manner similar to other addictive drugs.

    Francis J. White in Nature Medicine (1998)