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Article
Impact of corpus callosum integrity on functional interhemispheric connectivity and cognition in healthy subjects
To examine the corpus callosum’s (CC) integrity in terms of fractional anisotropy (FA) and how it affects resting-state hemispheric connectivity (rs-IHC) and cognitive function in healthy individuals. Sixty-ei...
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Article
Geographic differences in the incidence of Huntington’s disease in Sardinia, Italy
The frequency of Huntington’s disease (HD) may vary considerably, with higher estimates in non-Asian populations. We have recently examined the prevalence of HD in the southern part of Sardinia, a large Italia...
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Article
Open AccessResha** cortical connectivity in traumatic spinal cord injury: a novel effect of hyperbaric oxygen therapy
Spinal cord injuries (SCIs) represent a severe neuro-traumatic occurrence and an excruciating social burden. Though the hyperbaric oxygen (HBO2) has been credited as a first line therapeutic resource for SCIs,...
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Article
VGF peptides as novel biomarkers in Parkinson’s disease
Parkinson’s disease (PD) is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra (SN). At disease onset, a diagnosis is often difficult. VGF peptides are abundant in the ...
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Article
Open Access‘Networks in the brain: from neurovascular coupling of the BOLD effect to brain functional architecture’
Recently, many academic research groups focused their attention on changes in human brain networks related to several kinds of pathologies and diseases. Generally speaking, Network Medicine promises to identif...
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Article
The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation
Acute sleep deprivation (SD) can trigger or exacerbate psychosis- and mania-related symptoms; the neurobiological basis of these complications, however, remains elusive. Given the extensive involvement of neur...
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Article
Open AccessAn unusual delusion of duplication in a patient affected by Dementia with Lewy bodies
Dementia with Lewy bodies (DLB) is the second most frequent diagnosis of progressive degenerative dementia in older people. Delusions are common features in DLB and, among them, Capgras syndrome represents the...
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Article
Capgras syndrome in Parkinson’s disease: two new cases and literature review
The Capgras syndrome (CS) is a rare psychiatric disorder. CS is classified as a delusional misidentification syndrome. Initially, CS was described in paranoid schizophrenia and schizoaffective disorders. CS ha...
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Article
Open AccessDifferential effects of phytotherapic preparations in the hSOD1 Drosophila melanogaster model of ALS
The present study was aimed at characterizing the effects of Withania somnifera (Wse) and Mucuna pruriens (Mpe) on a Drosophila melanogaster model for Amyotrophic Lateral Sclerosis (ALS). In particular, the effec...
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Article
Open AccessEEG functional network topology is associated with disability in patients with amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis (ALS) is one of the most severe neurodegenerative diseases, which is known to affect upper and lower motor neurons. In contrast to the classical tenet that ALS represents the outc...
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Article
Parkinsonism and dementia are negative prognostic factors for the outcome of subdural hematoma
To determine, among a population with subdural hematoma (SH), whether patients affected by neurodegenerative disorders (parkinsonism and dementia) have a worse clinical outcome. We reviewed the data of patient...
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Article
C9ORF72 intermediate repeat expansion in patients affected by atypical parkinsonian syndromes or Parkinson’s disease complicated by psychosis or dementia in a Sardinian population
The hexanucleotide repeat expansion GGGGCC in the C9ORF72 gene larger than 30 repeats has been identified as a major genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recent ...
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Article
Heart rate variability shows different cardiovascular modulation in Parkinson’s disease patients with tremor dominant subtype compared to those with akinetic rigid dominant subtype
Parkinson’s disease (PD) can present with different motor subtypes depending on the predominant symptoms (tremor or rigidity/bradykinesia). Slower disease progression and less cognitive decline are observed in...
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Article
Rasagiline and Pisa syndrome in Parkinson’s disease patients
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Article
Clinical phenotypes and radiological findings in frontotemporal dementia related to TARDBP mutations
It has been shown that different genes could be associated with distinctive clinical and radiological phenotypes of FTD. TARDBP gene has been described worldwide in few cases of FTD so its phenotype is still u...
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Article
Delusional jealousy in Parkinson’s disease patients with and without dementia
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Article
Association between fatigue and other motor and non-motor symptoms in Parkinson’s disease patients
Although fatigue is a common non-motor symptom in patients affected by Parkinson’s disease (PD), its association with motor and other non-motor symptoms is still largely unclear. We assessed fatigue in PD pati...
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Article
The p.A382T TARDBP gene mutation in Sardinian patients affected by Parkinson's disease and other degenerative parkinsonisms
Based on our previous finding of the p.A382T founder mutation in ALS patients with concomitant parkinsonism in the Sardinian population, we hypothesized that the same variant may underlie Parkinson's disease (...
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Article
Bipolar affective disorder preceding frontotemporal dementia in a patient with C9ORF72 mutation: is there a genetic link between these two disorders?
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Article
Dopaminergic-induced paraphilias associated with impulse control and related disorders in patients with Parkinson disease
