5 Result(s)
within
Francesca De Vito
Biomedicine
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Article
Open AccessInterleukin-9 protects from microglia- and TNF-mediated synaptotoxicity in experimental multiple sclerosis
Multiple sclerosis (MS) is a progressive neurodegenerative disease of the central nervous system characterized by inflammation-driven synaptic abnormalities. Interleukin-9 (IL-9) is emerging as a pleiotropic c...
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Article
miR-135a Regulates Synaptic Transmission and Anxiety-Like Behavior in Amygdala
MicroRNAs are a class of non-coding RNAs with a growing relevance in the regulation of gene expression related to brain function and plasticity. They have the potential to orchestrate complex phenomena, such a...
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Article
Open AccessLaquinimod ameliorates excitotoxic damage by regulating glutamate re-uptake
Laquinimod is an immunomodulatory drug under clinical investigation for the treatment of the progressive form of multiple sclerosis (MS) with both anti-inflammatory and neuroprotective effects. Excitotoxicity,...
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Article
Open AccessInteraction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis
Mood disorders, including anxiety and depression, are frequently diagnosed in multiple sclerosis (MS) patients, even independently of the disabling symptoms associated with the disease. Anatomical, biochemical...
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Article
Open AccessSiponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis
Data from multiple sclerosis (MS) and the MS rodent model, experimental autoimmune encephalomyelitis (EAE), highlighted an inflammation-dependent synaptopathy at the basis of the neurodegenerative damage causi...
