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Article
Open AccessAssociation between augmented levels of the gut pro-hormone Proneurotensin and subclinical vascular damage
Elevated levels of the gut pro-hormone Proneurotensin (proNT) have been found to predict development of cardiovascular disease. However, it is still unknown whether higher proNT levels are associated with subc...
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Article
Open AccessInterleukin-9 protects from microglia- and TNF-mediated synaptotoxicity in experimental multiple sclerosis
Multiple sclerosis (MS) is a progressive neurodegenerative disease of the central nervous system characterized by inflammation-driven synaptic abnormalities. Interleukin-9 (IL-9) is emerging as a pleiotropic c...
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Article
Delayed treatment of MS is associated with high CSF levels of IL-6 and IL-8 and worse future disease course
Clinical deterioration of relapsing–remitting MS (RR-MS) patients reflects not only the number and severity of overt inflammatory and demyelinating episodes, but also subtle central damage caused by persistent...
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Article
miR-135a Regulates Synaptic Transmission and Anxiety-Like Behavior in Amygdala
MicroRNAs are a class of non-coding RNAs with a growing relevance in the regulation of gene expression related to brain function and plasticity. They have the potential to orchestrate complex phenomena, such a...
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Article
Open AccessLaquinimod ameliorates excitotoxic damage by regulating glutamate re-uptake
Laquinimod is an immunomodulatory drug under clinical investigation for the treatment of the progressive form of multiple sclerosis (MS) with both anti-inflammatory and neuroprotective effects. Excitotoxicity,...
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Article
Open AccessInteraction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis
Mood disorders, including anxiety and depression, are frequently diagnosed in multiple sclerosis (MS) patients, even independently of the disabling symptoms associated with the disease. Anatomical, biochemical...
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Article
Open AccessSiponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis
Data from multiple sclerosis (MS) and the MS rodent model, experimental autoimmune encephalomyelitis (EAE), highlighted an inflammation-dependent synaptopathy at the basis of the neurodegenerative damage causi...
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Article
Synaptopathy connects inflammation and neurodegeneration in multiple sclerosis
Progressive synaptic loss and dysfunction—also known as synaptopathy—occur early in multiple sclerosis (MS), and in experimental autoimmune encephalomyelitis (...
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Article
Pulse Duration and Efficiency of Soft Cellular Tissue Disintegration by Pulsed Electric Fields
The effect of pulse duration on efficiency of disintegration of apple tissue by pulsed electric fields (PEF) was studied. The samples (26-mm diameter, 10-mm height) were treated by PEF at electric field strength
