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Article
Open AccessDifferent effects of NK cells and NK-derived soluble factors on cell lines derived from primary or metastatic pancreatic cancers
Natural killer (NK) cells are cytotoxic lymphoid cells that play a key role in defenses against tumors. However, their function may be severely impaired in patients with pancreatic adenocarcinoma (PA). Indeed,...
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Article
Open AccessPolymorphonuclear myeloid-derived suppressor cells impair the anti-tumor efficacy of GD2.CAR T-cells in patients with neuroblastoma
The outcome of patients affected by high-risk or metastatic neuroblastoma (NB) remains grim, with ≥ 50% of the children experiencing relapse or progression of the disease despite multimodal, intensive treatmen...
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Article
Daratumumab induces mechanisms of immune activation through CD38+ NK cell targeting
Daratumumab (Dara), a multiple myeloma (MM) therapy, is an antibody against the surface receptor CD38, which is expressed not only on plasma cells but also on NK cells and monocytes. Correlative data have high...
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Article
Open AccessPMN-MDSC are a new target to rescue graft-versus-leukemia activity of NK cells in haplo-HSC transplantation