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Article
Clinical characterization and cytokine profile of fatigue in hematologic malignancy patients with chronic graft-versus-host disease
Limited information is available regarding clinical and biological properties of fatigue in patients with chronic graft-versus-host disease (cGvHD). Patients with moderate-to-severe cGvHD per NIH criteria were...
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Article
Serial changes in lymphocyte subsets in patients with newly diagnosed high grade astrocytomas treated with standard radiation and temozolomide
The immune system plays a significant role in cancer prevention and outcome. In high grade astrocytomas (HGA), severe lymphopenia is associated with shortened survival due to tumor progression. This study was ...
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Chapter
Chronic Graft Versus Host Disease: Inflammation at the Crossroads of Allo and Auto Immunity
The mechanisms underlying the pathogenesis of chronic graft versus host disease (CGVHD) remain obscure, despite the clinical importance of this disorder in transplant recipients. In this chapter we review curr...
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Chapter
Aging, Immunity and Cancer
Although the increased incidence of common cancers with age on one hand and immunosenescence on the other are both well documented in animal models and in humans, evidence for a causal link between the two is ...
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Chapter
Thymic Involution and Thymic Renewal
A primary factor in immunosenescence, the age-dependent deterioration in immune function, is the decline in the capacity to generate naïve T-cells due to thymic involution. The thymus reaches its greatest size...
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Protocol
Thymic Involution
The thymus contributes to the regulation of tolerance and the prevention of autoimmunity at many levels. First, auto-reactive CD4+ and CD8+ T cells are clonally deleted during negative selection in the thymus, es...
