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Open AccessTAD boundary deletion causes PITX2-related cardiac electrical and structural defects
While 3D chromatin organization in topologically associating domains (TADs) and loops mediating regulatory element-promoter interactions is crucial for tissue-specific gene regulation, the extent of their invo...
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Article
Open AccessIdentification of atrial fibrillation associated genes and functional non-coding variants
Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expressio...
