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Chapter
Stem Cell-Derived Extracellular Vesicles (EVs) for Disease Therapy
Stem cell therapy has become one of the most advanced technologies in the field of regenerative medicine and has attracted considerable attention worldwide. Recent studies have revealed that stem cells exert t...
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Article
Open AccessHypoxic preconditioned MSCs-derived small extracellular vesicles for photoreceptor protection in retinal degeneration
Photoreceptor apoptosis is an important pathogenesis of retinal degeneration and a primary cause of vision loss with limited treatment methods. Mesenchymal stem/stromal cells-derived small extracellular vesicl...
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Article
Engineered Extracellular Vesicles as a Targeted Delivery Platform for Precision Therapy
Extracellular vesicles (EVs)-based cell-free strategy has shown therapeutic potential in tissue regeneration. Due to their important roles in intercellular communications and their natural ability to shield ca...
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Article
Open AccessMesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4
As a leading cause of vision decline and severe blindness in adults, diabetic retinopathy (DR) is characterized by the aggravation of retinal oxidative stress and apoptosis in the early stage. Emerging studies...
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Article
Open AccessExosomes derived from hucMSC attenuate renal fibrosis through CK1δ/β-TRCP-mediated YAP degradation
Exosomes from human umbilical cord mesenchymal stem cells (hucMSC-Ex) have been suggested as novel nanomaterials for regenerative medicine. Here we explored the roles of hucMSC-Ex through regulating Yes-associ...