![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Immunoaffinity Nanoprobe-Based MALDI-TOF MS for Detection of Fragments of N-Telopeptides of Type I Collagen
Osteoporosis is one of the major bone-related diseases. Among the biomarkers of bone resorption, type I collagen cross-linked N-telopeptides (NTx) are terminal metabolites specifically derived from the degrada...
-
Article
Design, synthesis, and evaluation of fluorescent cell-penetrating peptidic antagonists of Grb2-SH2 for targeting MCF-7 breast cancer cells
The growth factor receptor-bound protein-Src homology 2 (Grb2-SH2) domain plays an important role in the oncogenic Ras signaling pathway, which is involved in cell proliferation and differentiation. We focused...
-
Chapter and Conference Paper
Surface Plasmon Resonance- and Quartz Crystal Microbalance-based Methods for Detecting GRB2 SH2 / Peptide Interaction
-
Chapter
Structure/activity studies of peptide library-based integrase inhibitors
-
Chapter
High affinity nonphosphorylated cyclic peptide inhibitors of Grb2-SH2/growth factor receptor interactions
-
Chapter
Novel non-phosphorylated peptides binding to the Grb2-SH2 domain
-
Chapter
Functional site studies with peptide segments of Cdk inhibitory proteins
-
Chapter
NMR based solution structure and dynamics of a nonphosphorylated cyclic peptide inhibitor for the Grb2 SH2 domain
-
Chapter
Stability and Peptide Binding Specificity of BTK SH2 Domain: Molecular Basis for X-Linked Agammaglobulinemia
X-Linked agammaglobulinemia (XLA), an inherited disease, is caused by mutations in the Bruton’s tyrosine kinase (BTK) [1]. Like many other cytoplasmic tyrosine kinases in signaling pathways, BTK contains an N-...
-
Chapter
Epitope Map** of Anti-Type I Collagen Crosslinked N-Telopeptide Antibody with Synthetic Peptides
Osteoporosis is a disease characterized by low bone mass and by architectural deterioration of bone tissue, two factors related to abnormalities of bone turnover [1,2]. This disease influences the health of me...
-
Chapter
Structure-Based Design, Synthesis, and Surface Plasmon Resonance (SPR) Detection of Antagonists of the Grb2 SH2 Domain
One of the critical intracellular signal transduction pathway involves the binding of Grb2 SH2 domain to the phosphotyrosine (pTyr) motifs on growth factors such as EGFR and erbB2, leading to downstream activa...
-
Article
Development of non-phosphorylated cyclic thioether peptide binding to the Grb2-SH2 domain
One of the critical intracellular signaling pathways involves specific interactions between growth factor receptors and the adaptor protein Grb2. These interactions normally involve specific tyrosine phosphory...
-
Article
Development of non-phosphorylated cyclic thioether peptide binding to the Grb2-SH2 domain
One of the critical intracellular signaling pathways involves specific interactions between growth factor receptors and the adaptor protein Grb2. These interactions normally involve specific tyrosine phosphory...