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  1. No Access

    Article

    The piRNA pathway is essential for generating functional oocytes in golden hamsters

    Piwi-interacting RNAs (piRNAs) are predominantly expressed in germ cells and function in gametogenesis in various species. However, Piwi-deficient female mice are fertile and mouse oocytes express a panel of smal...

    Hongdao Zhang, Fengjuan Zhang, Qinghua Chen, Mingzhe Li, **aolong Lv… in Nature Cell Biology (2021)

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    Article

    Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study

    Emerging evidence suggests that children conceived through assisted reproductive technology (ART) have a higher risk of congenital heart defects (CHDs) even when there is no family history. De novo mutation (D...

    Cheng Wang, Hong Lv, **ufeng Ling, Hong Li, Feiyang Diao, Juncheng Dai… in Cell Research (2021)

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    Article

    In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids

    Unlike most organs that mature during the fetal period, the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis. Robust modelling of human testicular organogenesi...

    Yan Yuan, Laihua Li, Qing Cheng, Feiyang Diao, Qiao Zeng, **aoyu Yang… in Cell Research (2020)