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Stem Cells and TCF Proteins: A Role for β-Catenin—Independent Functions
The Wnt signal transduction pathway has been shown to stimulate stem cell self renewal and has been shown to cause cancer in humans. One interesting aspect of Wnt signaling is that it utilizes downstream DNA-b...
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Article
Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal
The co-occupancy of Tcf3 with Oct4, Sox2 and Nanog on embryonic stem cell (ESC) chromatin indicated that Tcf3 has been suggested to play an integral role in a poorly understood mechanism underlying Wnt-depende...
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Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs
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Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy
Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug discovery. Human hepatocytes or hepatocyte-like cell...
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Rejuvenating liver and pancreas through cell transdifferentiation
Induced pluripotent stem cells (iPSCs) and the cell transdifferentiation technologies are providing powerful tools to generate patient-specific cells for research and therapeutic applications. Hepatocytes and ...
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Induced neural stem cells: a new tool for studying neural development and neurological disorders
Recent advances in the generation of multipotent and expandable induced neural stem cells are exciting. They not only hold great promises for potential clinical applications but may also open up a new era for ...
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Article
Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis
Dracorhodin perchlorate has been recently shown to induce apoptotic cell death in cancer cells. However, the molecular mechanisms underlying these effects are unknown in human gastric tumor cells. In this stud...
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Establishment of hepatic and neural differentiation platforms of Wilson’s disease specific induced pluripotent stem cells
The combination of disease-specific human induced pluripotent stem cells (iPSC) and directed cell differentiation offers an ideal platform for modeling and studying many inherited human diseases. Wilson’s dise...
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Article
Huntington's disease: Dancing in a dish
In a recent landmark paper, the Huntington's disease (HD) iPSC Consortium reports on the establishment and characterization of a panel of iPSC lines from HD patients, and more importantly, the successful model...
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The dawn of angiogenesis modeling: regenerating vasculature from human pluripotent stem cells
Efficient generation of functional human vascular endothelial cells and smooth muscle cells from pluripotent stem cells is an extensively studied topic and of great interest in the stem cell field. Though thou...
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Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism
Recent studies have been raising doubts on the safety of induced pluripotent stem cells (iPSCs) and proposing that the process of reprogramming brought about copy number variations (CNVs) in iPSCs. However, a ...
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Article
Beating in a dish: new hopes for cardiomyocyte regeneration
Functional human cardiomyocytes hold great promise in cell transplantation-based therapy to treat many heart diseases. To meet this devastating and clinical need, researchers are infatuated with develo** nov...
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Open AccessDirect reprogramming of porcine fibroblasts to neural progenitor cells
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Open AccessDirect conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors
The generation of functional retinal pigment epithelium (RPE) is of great therapeutic interest to the field of regenerative medicine and may provide possible cures for retinal degenerative diseases, including ...
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Open AccessGlobal DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes
With defined culture protocol, human embryonic stem cells (hESCs) are able to generate cardiomyocytes in vitro, therefore providing a great model for human heart development, and holding great potential for cardi...
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Regenerative medicine: Transdifferentiation in vivo
A major challenge in regenerative medicine is the generation of functionally effective target cells to replace or repair damaged tissues. Transdifferentiation in vivo is a novel strategy to achieve cell fate conv...
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Regeneration: making muscle from hPSCs
In recent years, researchers worldwide have developed protocols to efficiently differentiate skeletal myogenic cells from human pluripotent stem cells through either ectopic gene expression or the use of small...
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Open AccessA widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells
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Open AccessEliminate mitochondrial diseases by gene editing in germ-line cells and embryos
Nuclease-based gene editing technologies have opened up opportunities for correcting human genetic diseases. For the first time, scientists achieved targeted gene editing of mitochondrial DNA in mouse oocytes ...
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Open AccessCRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with cellular and molecular mechanisms yet to be fully described. Mutations in a number of genes including SOD1 and FUS are associated wi...