23 Result(s)

Article

De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity

Oncogenic stress induces DNA damage repair (DDR) that permits escape from mitotic catastrophe and allows early precursor lesions during the evolution of cancer. SAMHD1, a dNTPase protecting cells from viral in...

**gwei Liu, Tingting Zhou, **ang Dong, Qiqiang Guo, Lixia Zheng, **aoxun Wang… in Oncogene (2023)

Article

RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression

Androgen receptor (AR) signaling drives prostate cancer (PC) progression. Androgen deprivation therapy (ADT) is temporally effective, whereas drug resistance inevitably develops. Abnormal expression of AR/ARV7...

Tingting Zhou, Shengli Wang, **aoyu Song, Wensu Liu, Fang Dong… in Cell Death & Disease (2022)

Article

SIRT1 modulates cell cycle progression by regulating CHK2 acetylation−phosphorylation

Both the stress-response protein, SIRT1, and the cell cycle checkpoint kinase, CHK2, play critical roles in aging and cancer via the modulation of cellular homeostasis and the maintenance of genomic integrity....

Wenyu Zhang, Yanling Feng, Qiqiang Guo, Wendong Guo… in Cell Death & Differentiation (2020)

Article

CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with cellular and molecular mechanisms yet to be fully described. Mutations in a number of genes including SOD1 and FUS are associated wi...

Lixia Wang, Fei Yi, Lina Fu, Ji** Yang, Si Wang, Zhaoxia Wang… in Protein & Cell (2017)

Article

Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos

Nuclease-based gene editing technologies have opened up opportunities for correcting human genetic diseases. For the first time, scientists achieved targeted gene editing of mitochondrial DNA in mouse oocytes ...

Si Wang, Fei Yi, **g Qu in Protein & Cell (2015)

Article

A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells

Zhichao Ding, Lina Sui, Ruotong Ren, Yanjun Liu, **uling Xu, Lina Fu… in Protein & Cell (2015)

Article

Regeneration: making muscle from hPSCs

In recent years, researchers worldwide have developed protocols to efficiently differentiate skeletal myogenic cells from human pluripotent stem cells through either ectopic gene expression or the use of small...

Lina Fu, Fei Yi, Guang-Hui Liu, Alejandro Ocampo, **g Qu… in Cell Research (2014)

Article

Regenerative medicine: Transdifferentiation in vivo

A major challenge in regenerative medicine is the generation of functionally effective target cells to replace or repair damaged tissues. Transdifferentiation in vivo is a novel strategy to achieve cell fate conv...

Lina Fu, Fei Yi, Guang-Hui Liu, Juan Carlos Izpisua Belmonte in Cell Research (2014)

Article

Direct reprogramming of porcine fibroblasts to neural progenitor cells

**u-Ling Xu, Ji-** Yang, Li-Na Fu, Ruo-Tong Ren, Fei Yi… in Protein & Cell (2014)

Article

Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors

The generation of functional retinal pigment epithelium (RPE) is of great therapeutic interest to the field of regenerative medicine and may provide possible cures for retinal degenerative diseases, including ...

Ke**g Zhang, Guang-Hui Liu, Fei Yi, Nuria Montserrat, Tomoaki Hishida… in Protein & Cell (2014)

Article

Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes

With defined culture protocol, human embryonic stem cells (hESCs) are able to generate cardiomyocytes in vitro, therefore providing a great model for human heart development, and holding great potential for cardi...

Ying Gu, Guang-Hui Liu, Nongluk Plongthongkum, Christopher Benner, Fei Yi… in Protein & Cell (2014)

Article

Beating in a dish: new hopes for cardiomyocyte regeneration

Functional human cardiomyocytes hold great promise in cell transplantation-based therapy to treat many heart diseases. To meet this devastating and clinical need, researchers are infatuated with develo** nov...

Ying Gu, Fei Yi, Guang-Hui Liu, Juan Carlos Izpisua Belmonte in Cell Research (2013)

Article

Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism

Recent studies have been raising doubts on the safety of induced pluripotent stem cells (iPSCs) and proposing that the process of reprogramming brought about copy number variations (CNVs) in iPSCs. However, a ...

Wensu Liu, Ming Li, **g Qu, Fei Yi, Guang-Hui Liu in Protein & Cell (2013)

Article

The dawn of angiogenesis modeling: regenerating vasculature from human pluripotent stem cells

Efficient generation of functional human vascular endothelial cells and smooth muscle cells from pluripotent stem cells is an extensively studied topic and of great interest in the stem cell field. Though thou...

Fei Yi, **g Qu, Guang-Hui Liu, Juan Carlos Izpisua Belmonte in Cell Research (2013)

Article

Huntington's disease: Dancing in a dish

In a recent landmark paper, the Huntington's disease (HD) iPSC Consortium reports on the establishment and characterization of a panel of iPSC lines from HD patients, and more importantly, the successful model...

Ke**g Zhang, Fei Yi, Guang-Hui Liu, Juan Carlos Izpisua Belmonte in Cell Research (2012)

Article

Establishment of hepatic and neural differentiation platforms of Wilson’s disease specific induced pluripotent stem cells

The combination of disease-specific human induced pluripotent stem cells (iPSC) and directed cell differentiation offers an ideal platform for modeling and studying many inherited human diseases. Wilson’s dise...

Fei Yi, **g Qu, Mo Li, Keiichiro Suzuki, Na Young Kim, Guang-Hui Liu… in Protein & Cell (2012)

Article

Induced neural stem cells: a new tool for studying neural development and neurological disorders

Recent advances in the generation of multipotent and expandable induced neural stem cells are exciting. They not only hold great promises for potential clinical applications but may also open up a new era for ...

Guang-Hui Liu, Fei Yi, Keiichiro Suzuki, **g Qu… in Cell Research (2012)

Article

Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy

Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug discovery. Human hepatocytes or hepatocyte-like cell...

Fei Yi, Guang-Hui Liu, Juan Carlos Izpisua Belmonte in Protein & Cell (2012)

Article

Rejuvenating liver and pancreas through cell transdifferentiation

Induced pluripotent stem cells (iPSCs) and the cell transdifferentiation technologies are providing powerful tools to generate patient-specific cells for research and therapeutic applications. Hepatocytes and ...

Fei Yi, Guang-Hui Liu, Juan Carlos Izpisua Belmonte in Cell Research (2012)