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Article
Open AccessA single-cell atlas of pig gastrulation as a resource for comparative embryology
Cell-fate decisions during mammalian gastrulation are poorly understood outside of rodent embryos. The embryonic disc of pig embryos mirrors humans, making them a useful proxy for studying gastrulation. Here w...
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Article
Open AccessA genomic toolkit for winged bean Psophocarpus tetragonolobus
A sustainable supply of plant protein is critical for future generations and needs to be achieved while reducing green house gas emissions from agriculture and increasing agricultural resilience in the face of...
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Article
Open AccessPaternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice
The underlying mechanisms driving paternally-programmed metabolic disease in offspring remain poorly defined. We fed male C57BL/6 mice either a control normal protein diet (NPD; 18% protein) or an isocaloric l...
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Article
Open AccessModifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging
Synaptic plasticity processes, which underlie learning and memory formation, require RNA to be translated local to synapses. The synaptic tagging hypothesis has previously been proposed to explain how mRNAs ar...
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Protocol
Bioinformatics Analysis of DNA Methylation Through Bisulfite Sequencing Data
DNA methylation plays an important role in the regulation of gene expression as one of the epigenetic modifications. The bisulfite sequencing is widely used to determine the patterns of genomic methylation as ...
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Article
Open AccessPluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis
High-resolution molecular programmes delineating the cellular foundations of mammalian embryogenesis have emerged recently. Similar analysis of human embryos is limited to pre-implantation stages, since early ...
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Article
Open AccessObservations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer’s disease
In order to determine how gene expression is altered in disease it is of fundamental importance that the global distribution of gene expression levels across the disease-free brain are understood and how diffe...
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Article
ReDB: A meiotic homologous recombination rate database
Meiotic recombination occurs preferentially at certain regions in the genome referred to as hot spots which are important for generating genetic diversity and proper segregation of chromosomes during meiosis. ...
