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Chapter
Fabrication Technology of Chitosan-Based IPN: Drug Delivery Application
Chitosan as a biocompatible and biodegradable polymer is a good candidate for preparation of interpenetrating polymer network (IPN) hydrogel with amino and hydroxyl groups. Chitosan-based IPNs can release thei...
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Article
Inhibiting hepatic gluconeogenesis by chitosan lactate nanoparticles containing CRTC2 siRNA targeted by poly(ethylene glycol)-glycyrrhetinic acid
Diabetes mellitus is a chronic metabolic disorder characterized by insulin deficiency and impaired glucose metabolism. Overexpression of cAMP response element binding protein (CREB)-regulated transcriptional c...
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Article
Corneal chemical burn treatment through a delivery system consisting of TGF-β1 siRNA: in vitro and in vivo
Chemical burns are major causes of corneal blindness. Transforming growth factor beta-1 (TGFβ1) plays an important role in induction of corneal inflammation-related-fibrosis leading to the blindness. Here, a topi...
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Article
Inhibiting influenza virus replication and inducing protection against lethal influenza virus challenge through chitosan nanoparticles loaded by siRNA
Influenza virus causes a highly contagious viral respiratory tract infection with potentially fatal outcomes in humans and animals. There is now widespread influenza virus resistance to commercial drugs due to...