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Article
Cytidine deaminase enzyme activity is a predictive biomarker in gemcitabine-treated cancer patients
Gemcitabine is a chemotherapeutic agent, widely used for the treatment of many types of cancer. Cytidine deaminase (CDA) enzyme plays an important role in the metabolism of gemcitabine. This study aimed to ass...
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Article
Open AccessEffect of Pb do** on the structural, optical and electrical properties of sol–gel ZnO nanoparticles
Pure and Pb-doped ZnO NPs were synthesized using the sol–gel method. The structural and morphological properties were investigated via XRD, FTIR and FE-SEM. A detailed study of the effect of Pb on the properti...
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Article
Open AccessNovel quinazoline-1,2,3-triazole hybrids with anticancer and MET kinase targeting properties
Oncogenic activation of receptor tyrosine kinases (RTKs) such as MET is associated with cancer initiation and progression. We designed and synthesized a new series of quinazoline derivatives bearing 1,2,3-tria...
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Article
Open AccessImidazopyridine hydrazone derivatives exert antiproliferative effect on lung and pancreatic cancer cells and potentially inhibit receptor tyrosine kinases including c-Met
Aberrant activation of c-Met signalling plays a prominent role in cancer development and progression. A series of 12 imidazo [1,2-α] pyridine derivatives bearing 1,2,3-triazole moiety were designed, synthesize...
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Article
Catalyst-free green synthesis of tetrahydro-benzo[b]pyrans in magnetized water: experimental aspects and molecular dynamics simulation
In this work, magnetized water is applied as a green-promoting medium for the catalyst-free, one-pot, practical, efficient, and environmentally benign multi-component synthesis of tetrahydrobenzo[b]pyrans. Some t...
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Article
Interaction of longitudinal phonons with discrete breather in strained graphene
We numerically analyze the interaction of small-amplitude phonon waves with standing gap discrete breather (DB) in strained graphene. To make the system support gap DB, strain is applied to create a gap in th...
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Article
A new method for preparing mono-dispersed nanoparticles using magnetized water
We studied the use of magnetized water on the size of the nanoparticles. Magnetized water found to reduce the diameter of the nanoparticles during a homogeneous precipitation process, which is a combination of...
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Article
Glycerol revisited molecular dynamic simulations of structural, dynamical, and thermodynamic properties
We performed molecular dynamics simulations to investigate the properties of glycerol for a wide range of temperatures at standard pressure. We calculated structural (radial distribution functions and pair pot...
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Article
Computer-aided analysis of structural properties and epitopes of Iranian HPV-16 E7 oncoprotein
Infection by human papillomavirus type 16 (HPV-16) is the cause of 50% or more of cervical cancers in women. The E7 oncoprotein of HPV-16 has long been known as a potent immortalizing and transforming agent. W...
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Article
Synthesis, characterization, ab initio calculations, thermal behaviour and thermodynamics of some oxovanadium(IV) complexes involving O,O- and N,N-donor moieties
Some oxovanadium(IV) complexes, namely bis(1,1,1-trifluro-2,4-pentanedionato-O,O′) oxovanadium (IV), [VO(tfac)2(H2O)], bis(1-phenyl-2,4-pentanedionato-O,O′)oxovanadium(IV), [VO(phac)2(H2O)], bis(1,3-diphenyl-2,4-...