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Article
Phosphodiesterase 8 (PDE8): Distribution and Cellular Expression and Association with Alzheimer’s Disease
Phosphodiesterase 8 (PDE8), as a member of PDE superfamily, specifically promotes the hydrolysis and degradation of intracellular cyclic adenosine monophosphate (cAMP), which may be associated with pathogenesi...
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Article
Open AccessA theoretical explanation for how a nutrition counseling and medically tailored meal delivery program benefitted participants living with lung cancer
The purpose of this study was to assess participants’ perceptions and experiences while participating in a Food is Medicine medically tailored meal plus intensive nutrition counseling intervention to create a ...
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Article
Imbalance of multiple neurotransmitter pathways leading to depression-like behavior and cognitive dysfunction in the triple transgenic mouse model of Alzheimer disease
Depression is among the most frequent psychiatric comorbid conditions in Alzheimer disease (AD). However, pharmacotherapy for depressive disorders in AD is still a big challenge, and the data on the efffcacy o...
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Article
Evidence-based nutrition guidelines for cancer survivors in Europe: a call for action
The aims of this study were to (1) document currently available guidelines aimed at healthcare professionals and including some information on the nutritional management of cancer survivors in Europe; (2) asse...
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Article
Implementing federal food service guidelines in federal and private worksite cafeterias in the United States leads to improved health outcomes and is cost saving
Poor diet increases cardiometabolic disease risk, yet the impact of food service guidelines on employee health and its cost effectiveness is poorly understood. Federal food service guidelines (FFSG) aim to pro...
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Article
Baicalin attenuates amyloid β oligomers induced memory deficits and mitochondria fragmentation through regulation of PDE-PKA-Drp1 signalling
Mitochondrial fragmentation contributes to the initiation of Alzheimer’s disease (AD) pathology. Baicalin plays a significant role in rescuing mitochondrial dysfunction. However, the effect of baicalin treatme...
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Article
Estimated economic burden of cancer associated with suboptimal diet in the United States
Suboptimal diet is a preventable cause of cancer. We aimed to estimate the economic burden of diet-associated cancer among US adults.
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Article
Correction to: lncRNA MEG3, Acting as a ceRNA, Modulates RPE Differentiation Through the miR-7-5p/Pax6 Axis
A correction to this paper has been published: https://doi.org/10.1007/s10528-021-10086-3
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Article
lncRNA MEG3, Acting as a ceRNA, Modulates RPE Differentiation Through the miR-7-5p/Pax6 Axis
Accumulated evidence indicated that long non-coding RNAs (lncRNAs) involves in numerous biological and pathological processes, including age-related macular degeneration (AMD). Dysfunction and dedifferentiatio...
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Article
Obesity-induced reduced expression of the lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation
Although obesity is a predisposing factor for pancreatic beta cell dysfunction, the mechanisms underlying its negative effect on insulin-secreting cells is still poorly understood. The aim of this study was to...
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Article
An empirical study on energy utilization efficiency, economic development, and sustainable management
Based on the premise of sustainable development of the environment, how to achieve the balance of energy utilization, economic development, and sustainable management of the environment is becoming increasingl...
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Article
The plasticity of root distribution and nitrogen uptake contributes to recovery of maize growth at late growth stages in wheat/maize intercrop**
Previous studies showed that the competition-recovery principle is one of the mechanisms underpinning overyielding in wheat/maize intercrop**. However, few studies have focused on the effects of root morphol...
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Article
Complex Modified Projective Synchronization for Fractional-order Chaotic Complex Systems
The aim of this paper is to study complex modified projective synchronization (CMPS) between fractional-order chaotic nonlinear systems with incommensurate orders. Based on the stability theory of incommensura...
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Article
Cyclic nucleotide phosphodiesterases: potential therapeutic targets for alcohol use disorder
Alcohol use disorder (AUD), which combines the criteria of both alcohol abuse and dependence, contributes as an important causal factor to multiple health and social problems. Given the limitation of current t...
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Article
Origin of the subduction-related Carboniferous intrusions associated with the Yandong porphyry Cu deposit in eastern Tianshan, NW China: constraints from geology, geochronology, geochemistry, and Sr–Nd–Pb–Hf–O isotopes
The Yandong porphyry Cu deposit is located at the south margin of the Dananhu–Tousuquan arc belt in eastern Tianshan, northwest China. The Cu ores comprise mainly disseminations and vein zones in the potassic ...
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Article
Early Nutrition and Physical Activity Interventions in Childhood Cancer Survivors
Childhood cancer survivors experience excessive weight gain early in treatment. Lifestyle interventions need to be initiated early in cancer care to prevent the early onset of obesity and cardiovascular diseas...
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Article
Catalytic chemiluminescent detection of cholesterol in serum with Cu2−x Se semiconductor nanoparticles
It is very important to be able to accurately and rapidly measure the cholesterol level in the human body, as cholesterol is associated with various diseases, such as Alzheimer’s disease. In this work, a novel...
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Article
Anti-tumor effects of DNA vaccine targeting human fibroblast activation protein α by producing specific immune responses and altering tumor microenvironment in the 4T1 murine breast cancer model
Fibroblast activation protein α (FAPα) is a tumor stromal antigen overexpressed by cancer-associated fibroblasts (CAFs). CAFs are genetically more stable compared with the tumor cells and immunosuppressive com...
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Article
Open AccessVitamin D deficiency is associated with high prevalence of diabetes in Kuwaiti adults: results from a national survey
Vitamin D homeostasis may play a critical role in glucose metabolism. Little is known on vitamin D deficiency and its association with diabetes in countries of the Arabia Gulf where the population is experienc...
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Article
Intravenous Thrombolytic Therapy for Acute Ischemic Stroke with Subclavian Arterial Steal Syndrome: A Case Report
