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  1. No Access

    Article

    Co-amorphous Drug Delivery Systems: a Review of Physical Stability, In Vitro and In Vivo Performance

    Over the past few decades, co-amorphous solids have been used as a promising approach for delivering poorly water-soluble drugs. Co-amorphous solids, comprising pharmacologically relevant drug substances or ex...

    Qin Shi, Yanan Wang, Sakib M. Moinuddin, **aodong Feng, Fakhrul Ahsan in AAPS PharmSciTech (2022)

  2. No Access

    Article

    Liposomal Aerosols of Nitric Oxide (NO) Donor as a Long-Acting Substitute for the Ultra-Short-Acting Inhaled NO in the Treatment of PAH

    This study seeks to develop a liposomal formulation of diethylenetriamine NONOate (DN), a long acting nitric oxide (NO) donor, with a goal to replace inhaled NO (iNO) in the treatment of pulmonary arterial hyp...

    Kamrun Nahar, Jahidur Rashid, Shahriar Absar… in Pharmaceutical Research (2016)

  3. No Access

    Article

    Aerosolized Montelukast Polymeric Particles—An Alternative to Oral Montelukast–Alleviate Symptoms of Asthma in a Rodent Model

    Cysteinyl leukotrienes (CysLTs) propagate inflammatory reactions that result from allergen exposure in asthma. Montelukast, a CysLT type-1 receptor antagonist, disrupts mediator–receptor interactions and minim...

    Brijeshkumar Patel, Nilesh Gupta, Fakhrul Ahsan in Pharmaceutical Research (2014)

  4. No Access

    Article

    Nano-Engineered Erythrocyte Ghosts as Inhalational Carriers for Delivery of Fasudil: Preparation and Characterization

    Nanoerythrosomes (NERs), an engineered derivative of erythrocytes, have long been used as drug delivery carriers. These cell based carriers are biocompatible and biodegradable, and they exhibit efficient drug ...

    Nilesh Gupta, Brijeshkumar Patel, Fakhrul Ahsan in Pharmaceutical Research (2014)

  5. No Access

    Article

    Thrombus-Targeted Nanocarrier Attenuates Bleeding Complications Associated with Conventional Thrombolytic Therapy

    To test the hypothesis that thrombus-specific tissue plasminogen activator (tPA)-loaded nanocarriers enhance thrombolytic efficacy and attenuate hemorrhagic complications.

    Shahriar Absar, Kamrun Nahar, Young Min Kwon, Fakhrul Ahsan in Pharmaceutical Research (2013)

  6. No Access

    Article

    PLGA Microparticles Encapsulating Prostaglandin E1-Hydroxypropyl-β-cyclodextrin (PGE1-HPβCD) Complex for the Treatment of Pulmonary Arterial Hypertension (PAH)

    To test the efficacy and viability of poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating an inclusion complex of prostaglandin E1 (PGE1) and 2-hydroxypropyl-β-cyclodextrin (HPβCD) for pulmonary deli...

    Vivek Gupta, Marauo Davis, Louisa J. Hope-Weeks, Fakhrul Ahsan in Pharmaceutical Research (2011)

  7. No Access

    Article

    Particle Size Influences the Immune Response Produced by Hepatitis B Vaccine Formulated in Inhalable Particles

    To test the hypothesis that particle size influences the magnitude of immune response produced by hepatitis B surface antigen (HBsAg) encapsulated in poly (lactic-co-glycolic acid) (PLGA) microspheres.

    Chandan Thomas, Vivek Gupta, Fakhrul Ahsan in Pharmaceutical Research (2010)

  8. No Access

    Article

    Synthesis and Evaluation of Pegylated Dendrimeric Nanocarrier for Pulmonary Delivery of Low Molecular Weight Heparin

    This study tests the hypothesis that pegylated dendrimeric micelles prolong the half-life of low molecular weight heparin (LMWH) and increase the drug’s pulmonary absorption, thereby efficacious in preventing ...

    Shuhua Bai, Fakhrul Ahsan in Pharmaceutical Research (2009)

  9. No Access

    Article

    Complexation of a Poly-l-Arginine with Low Molecular Weight Heparin Enhances Pulmonary Absorption of the Drug

    This study tests the hypothesis that complexation between a cationic polymer, poly-l-arginine (PLA), and an anionic drug, low molecular weight heparin (LMWH), enhances pulmonary absorption and reduces the epithel...

    Amit Rawat, Tianzhi Yang, Alamdar Hussain, Fakhrul Ahsan in Pharmaceutical Research (2008)

  10. No Access

    Article

    Inhaled Insulin is Better Absorbed When Administered as a Dry Powder Compared to Solution in the Presence or Absence of Alkylglycosides

    This study was performed to investigate the safety of alkylglycosides administered via the respiratory route and to compare the pulmonary absorption profiles of insulin administered as dry powder inhaler and i...

    Alamdar Hussain, Quamrul H. Majumder, Fakhrul Ahsan in Pharmaceutical Research (2006)

  11. No Access

    Article

    Pulmonary Delivery of Low Molecular Weight Heparins

    Purpose. To investigate if pulmonary delivery of low molecular weight heparin (LMWH) formulated with tetradecyl-β-maltoside (TDM) or dimethyl-β-cyclodextrin (DMβCD) could be a feasible alternative to subcutaneou...

    Tianzhi Yang, Fatima Mustafa, Shuhua Bai, Fakhrul Ahsan in Pharmaceutical Research (2004)

  12. No Access

    Article

    Cyclodextrins in Nasal Delivery of Low-Molecular-Weight Heparins: In Vivo and in Vitro Studies

    Purpose. To test the hypothesis that cyclodextrins reversibly enhance nasal absorption of low-molecular-weight heparins (LMWHs) and to investigate the mechanisms by which cyclodextrins enhance LMWH absorption vi...

    Tianzhi Yang, Alamdar Hussain, Jennifer Paulson… in Pharmaceutical Research (2004)

  13. No Access

    Article

    Pulmonary Absorption of Insulin Mediated by Tetradecyl-β-Maltoside and Dimethyl-β-Cyclodextrin

    Purpose. To determine if tetradecyl-β-maltoside (TDM) and dimethyl-β-cyclodextrin (DMβCD) enhance pulmonary absorption of insulin and to investigate if they do so by a reversible action on respiratory epithelium...

    Alamdar Hussain, Tianzhi Yang, Abdel-Azim Zaghloul… in Pharmaceutical Research (2003)

  14. No Access

    Article

    Enhanced Bioavailability of Calcitonin Formulated with Alkylglycosides Following Nasal and Ocular Administration in Rats

    Purpose. The purpose of this study was to characterize the effects of alkylglycosides on the bioavailability of calcitonin following nasal and ocular administration.

    Fakhrul Ahsan, John Arnold, Elias Meezan, Dennis J. Pillion in Pharmaceutical Research (2001)

  15. No Access

    Article

    Mutual Inhibition of the Insulin Absorption-Enhancing Properties of Dodecylmaltoside and Dimethyl-β-cyclodextrin Following Nasal Administration

    Purpose. To determine if a nasal insulin formulation containing two distinct absorption–enhancing agents exhibits an additive or synergistic increase in the rate of systemic insulin absorption.

    Fakhrul Ahsan, John J. Arnold, Elias Meezan, Dennis J. Pillion in Pharmaceutical Research (2001)

  16. No Access

    Chapter and Conference Paper

    Interactions of Surfactants with Tolbutamide-ß-Cyclodextrin Inclusion Compound: The Consequence in Drug Dissolution

    Cyclodextrins are now used extensively in all sorts of pharmaceutical formulations such as tablets, capsules, sachets, ointments and suppositories etc [1]. However, studies on the interactions between drug-cyc...

    María-Dolores Veiga, Fakhrul Ahsan in Proceedings of the Ninth International Sym… (1999)

  17. No Access

    Chapter and Conference Paper

    Hydroxypropyl Gamma Cyclodextrin as a Solubiliser and Dissolution Enhancing Agent: The Case of Tolbutamide—A Poorly Water-Soluble Drug

    Hydroxypropyl cyclodextrins are one of the most freely soluble cyclodextrin derivatives. These cyclodextrins have been found very useful in parenteral preparations [1] and in solid dosage forms [2] because of ...

    María-Dolores Veiga, Fakhrul Ahsan in Proceedings of the Ninth International Sym… (1999)

  18. No Access

    Chapter and Conference Paper

    Differential Scanning Calorimetry as an Analytical Tool in Determining the Interaction Between Drug and Cyclodextrin

    Differential Scanning Calorimetry is a widely used analytical method in the study of multicomponent solid systems to reveal the possible changes during heating [1–3]. Its importance in the characterisation of ...

    María-Dolores Veiga, Fakhrul Ahsan… in Proceedings of the Ninth International Sym… (1999)