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  1. No Access

    Article

    High efficiency intranasal drug delivery using Intravail® alkylsaccharide absorption enhancers

    A new class of alkylsaccharide transmucosal delivery enhancement agents are described that overcome the principal limitations preventing broad acceptance of intranasal administration for many potential applica...

    Edward T. Maggio, Dennis J. Pillion in Drug Delivery and Translational Research (2013)

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    Article

    Enhanced Bioavailability of Calcitonin Formulated with Alkylglycosides Following Nasal and Ocular Administration in Rats

    Purpose. The purpose of this study was to characterize the effects of alkylglycosides on the bioavailability of calcitonin following nasal and ocular administration.

    Fakhrul Ahsan, John Arnold, Elias Meezan, Dennis J. Pillion in Pharmaceutical Research (2001)

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    Article

    Mutual Inhibition of the Insulin Absorption-Enhancing Properties of Dodecylmaltoside and Dimethyl-β-cyclodextrin Following Nasal Administration

    Purpose. To determine if a nasal insulin formulation containing two distinct absorption–enhancing agents exhibits an additive or synergistic increase in the rate of systemic insulin absorption.

    Fakhrul Ahsan, John J. Arnold, Elias Meezan, Dennis J. Pillion in Pharmaceutical Research (2001)

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    Article

    Dodecylmaltoside-Mediated Nasal and Ocular Absorption of Lyspro-Insulin: Independence of Surfactant Action from Multimer Dissociation

    Dennis J. Pillion, Susan Hosmer, Elias Meezan in Pharmaceutical Research (1998)

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    Article

    Binding and degradation of125I-insulin by isolated rat renal brush border membranes: Evidence for low affinity, high capacity insulin recognition sites

    The kidney plays a major role in the handling of circulating insulin in the blood, primarily via reuptake of filtered insulin at the luminal brush border membrane.125I-insulin associated with rat renal brush bord...

    Elias Meezan, Dennis J. Pillion, Ada Elgavish in The Journal of Membrane Biology (1988)

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    Article

    The role of glutathione in renal cortical tissue. effects of diamide on Na+ and GSSG levels, amino acid transport and Na+-K+-ATPase activity

    The effects of diamide were studied in rat kidney cortical tissue. It was found that diamide increased oxidized glutathione levels and inhibited Na+-K+-ATPase activity. Consistent with this finding was the observ...

    Dennis J. Pillion, Lamar Moree, Hector Rocha… in Molecular and Cellular Biochemistry (1977)