15 Result(s)

Article

Head and neck cancer of unknown primary: unveiling primary tumor sites through machine learning on DNA methylation profiles

The unknown tissue of origin in head and neck cancer of unknown primary (hnCUP) leads to invasive diagnostic procedures and unspecific and potentially inefficient treatment options for patients. The most commo...

Leonhard Stark, Atsuko Kasajima, Fabian Stögbauer, Benedikt Schmidl… in Clinical Epigenetics (2024)

Article

Digitalisierung der histopathologischen Routinediagnostik

Die Digitalisierung des histopathologischen Eingangslabors ist ein wichtiger und entscheidender Schritt in der digitalen Transformation der Pathologie. Digitalisierung ermöglicht zahlreiche neue Optionen wie d...

Viola Iwuajoku, Anette Haas, Kübra Ekici, Mohammad Zaid Khan… in Die Pathologie (2024)

Article

Integrated Molecular and Histological Insights for Targeted Therapies in Mesenchymal Sinonasal Tract Tumors

This review aims to provide a comprehensive overview of mesenchymal sinonasal tract tumors (STTs), a distinct subset of STTs. Despite their rarity, mesenchymal STTs represent a unique clinical challenge, chara...

Cosima C. Hoch, Leonard Knoedler, Samuel Knoedler… in Current Oncology Reports (2024)

Article

Correction: Tumour budding-based grading as independent prognostic biomarker in HPV-positive and HPV-negative head and neck cancer

Fabian Stögbauer, Susanne Beck, Iordanis Ourailidis… in British Journal of Cancer (2024)

Article

Predicting HPV association using deep learning and regular H&E stains allows granular stratification of oropharyngeal cancer patients

Human Papilloma Virus (HPV)-associated oropharyngeal squamous cell cancer (OPSCC) represents an OPSCC subgroup with an overall good prognosis with a rising incidence in Western countries. Multiple lines of evi...

Sebastian Klein, Nora Wuerdemann, Imke Demers, Christopher Kopp… in npj Digital Medicine (2023)

Article

Tumour budding-based grading as independent prognostic biomarker in HPV-positive and HPV-negative head and neck cancer

The prognostic significance of tumour budding (TB) and minimal cell nest size (MCNS) was shown in human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC). However, the optimisation o...

Fabian Stögbauer, Susanne Beck, Iordanis Ourailidis… in British Journal of Cancer (2023)

Article

Comparison of PD-L1 expression in squamous cell cancer of unknown primary and oropharyngeal squamous cell carcinoma

The tumorigenesis of squamous cell cancer of unknown primary (SCCUP) in the head and neck area has not been decoded so far, while poor survival rates and limited therapeutic options pose a serious challenge. T...

Benedikt Schmidl, Kim-Aylin Voßenkämper… in European Archives of Oto-Rhino-Laryngology (2023)

Article

Fibroossäre, riesenzellhaltige und hämatolymphoide Kieferläsionen

Die Weltgesundheitsorganisation (WHO) unterteilt die odontogenen und maxillofazialen Knochentumoren in gutartige und bösartige Knochen- und Knorpeltumoren, Kieferzysten, odontogene Tumoren sowie Riesenzellläsi...

PD Dr. Dr. Andreas Maximilian Fichter, Fabian Stögbauer… in Die MKG-Chirurgie (2023)

Article

Correction to: A six-gene expression signature related to angiolymphatic invasion is associated with poor survival in laryngeal squamous cell carcinoma

Karl Metzger, Julius Moratin, Kolja Freier… in European Archives of Oto-Rhino-Laryngology (2022)

Article

The immunologic tumor microenvironment in endometrioid endometrial cancer in the morphomolecular context: mutual correlations and prognostic impact depending on molecular alterations

POLE-mutant, microsatellite-instable (MSI), p53-mutant and non-specific molecular profile (NSMP) are TCGA-defined molecular subgroups of endometrial cancer (EC). Hypothesizing that morphology and tumor immunol...

Barbara Willvonseder, Fabian Stögbauer, Katja Steiger… in Cancer Immunology, Immunotherapy (2021)

Article

A six-gene expression signature related to angiolymphatic invasion is associated with poor survival in laryngeal squamous cell carcinoma

Angiolymphatic invasion serves as a histopathological risk factor for unfavorable survival in head and neck squamous cell carinoma. The aim of the study was to explore  the molecular mechanisms characterizing ...

Karl Metzger, Julius Moratin, Kolja Freier… in European Archives of Oto-Rhino-Laryngology (2021)

Article

Pre-operative cellular dissociation grading in biopsies is highly predictive of post-operative tumour stage and patient outcome in head and neck squamous cell carcinoma

Pre-operative treatment planning in head and neck squamous cell carcinoma (HNSCC) is mainly dictated by clinical staging, which has major shortcomings. Histologic grading is irrelevant due to its lack of progn...

Moritz Jesinghaus, Katja Steiger, Fabian Stögbauer… in British Journal of Cancer (2020)

Article

The BRCA2 mutation status shapes the immune phenotype of prostate cancer

Defects in DNA damage repair caused by mutations in BRCA1/2, ATM or other genes have been shown to play an important role in the development and progression of prostate cancer. The influence of such mutations on ...

Maximilian Jenzer, Peter Keß, Cathleen Nientiedt… in Cancer Immunology, Immunotherapy (2019)

Article

Annexin A6 is highly abundant in monocytes of obese and type 2 diabetic individuals and is downregulated by adiponectin in vitro

Adiponectin stimulates cholesterol efflux in macrophages and low adiponectin may in part contribute to disturbed reverse cholesterol transport in type 2 diabetes. Monocytes express high levels of annexin A6 th...

Fabian Stögbauer, Johanna Weigert, Markus Neumeier… in Experimental & Molecular Medicine (2009)