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Article
Open AccessSex differences in long-term kidney fibrosis following neonatal nephron loss during ongoing nephrogenesis
Clinical studies suggest that female sex plays a protective role in the development and progression of kidney disease. Recent experimental studies indicate that in male rats early nephron loss under ongoing ne...
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Article
Open AccessHigh-resolution label-free map** of murine kidney vasculature by raster-scanning optoacoustic mesoscopy: an ex vivo study
Chronic kidney disease (CKD) is a global burden affecting both children and adults. Novel imaging modalities hold great promise to visualize and quantify structural, functional, and molecular organ damage. The...
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Article
Open AccessInfluence of labor on direct and indirect determinants of placental 11beta-hydroxysteroid dehydrogenase activity
Labor is a complex process involving multiple para-, auto- and endocrine cascades. The interaction of cortisol, corticotropin-releasing hormone (CRH) and progesterone is essential. The action of cortisol on th...
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Article
Open AccessSex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8
Apoe-deficient (Apoe −/−) mice develop progressive atherosclerotic lesions with age but no severe renal pathology in the absence of additional challenges. We...
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Article
Open AccessCorticotropin-releasing hormone stimulates expression of leptin, 11beta-HSD2 and syncytin-1 in primary human trophoblasts
The placental syncytiotrophoblast is the major source of maternal plasma corticotropin-releasing hormone (CRH) in the second half of pregnancy. Placental CRH exerts multiple functions in the maternal organism:...