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Article
Open AccessSurvey in radiation oncology departments in Germany, Austria, and Switzerland: state of digitalization by 2023
The aim of this work was to assess the current state of digitalization in radiation oncology departments in Germany, Austria, and Switzerland.
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Article
Open AccessSex differences in long-term kidney fibrosis following neonatal nephron loss during ongoing nephrogenesis
Clinical studies suggest that female sex plays a protective role in the development and progression of kidney disease. Recent experimental studies indicate that in male rats early nephron loss under ongoing ne...
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Article
Open AccessMobile applications in radiation oncology—current choices and future potentials
To review existing scientific literature on mobile applications (apps) in the field of radiation oncology and to evaluate characteristics of commercially available apps across different platforms.
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Article
Open AccessHigh-resolution label-free map** of murine kidney vasculature by raster-scanning optoacoustic mesoscopy: an ex vivo study
Chronic kidney disease (CKD) is a global burden affecting both children and adults. Novel imaging modalities hold great promise to visualize and quantify structural, functional, and molecular organ damage. The...
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Article
Open AccessRNA sequencing reveals induction of specific renal inflammatory pathways in a rat model of malignant hypertension
In malignant hypertension, far more severe kidney injury occurs than in the “benign” form of the disease. The role of high blood pressure and the renin–angiotensin–aldosterone system is well recognized, but th...
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Article
Open AccessInfluence of labor on direct and indirect determinants of placental 11beta-hydroxysteroid dehydrogenase activity
Labor is a complex process involving multiple para-, auto- and endocrine cascades. The interaction of cortisol, corticotropin-releasing hormone (CRH) and progesterone is essential. The action of cortisol on th...
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Article
Open AccessPrevalence of metastases within the hypothalamic-pituitary area in patients with brain metastases
To quantify the prevalence of brain metastases involving the hypothalamic-pituitary (HT-P) area.
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Multisite measurement of regional oxygen saturation in Fontan patients with and without protein-losing enteropathy at rest and during exercise
Protein-losing enteropathy (PLE) is a severe complication of Fontan circulation with increased risk of end-organ dysfunction. We evaluated tissue oxygenation via near-infrared spectroscopy (NIRS) at different ...
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Article
Attenuation of Mammary Gland Dysplasia and Feeding Difficulties in Tabby Mice by Fetal Therapy
Hypohidrotic ectodermal dysplasias (HED) are hereditary differentiation disorders of multiple ectodermal structures including the mammary gland. The X-linked form of HED (XLHED) is caused by a lack of the secr...
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Open AccessNeonatal nephron loss during active nephrogenesis – detrimental impact with long-term renal consequences
Neonatal nephron loss may follow hypoxic-ischemic events or nephrotoxic medications. Its long-term effects on the kidney are still unclear. Unlike term infants, preterm neonates less than 36 weeks gestational ...
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Open AccessSex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8
Apoe-deficient (Apoe −/−) mice develop progressive atherosclerotic lesions with age but no severe renal pathology in the absence of additional challenges. We...
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Article
Open Accessp45 NF-E2 regulates syncytiotrophoblast differentiation by post-translational GCM1 modifications in human intrauterine growth restriction
Placental insufficiency jeopardizes prenatal development, potentially leading to intrauterine growth restriction (IUGR) and stillbirth. Surviving fetuses are at an increased risk for chronic diseases later in ...
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Article
Trophoblast expression dynamics of the tumor suppressor gene gastrokine 2
Gastrokines (GKNs) were originally described as stomach-specific tumor suppressor genes. Recently, we identified GKN1 in extravillous trophoblasts (EVT) of human placenta. GKN1 treatment reduced the migration ...
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Article
Open AccessThymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer
Thymoquinone (TQ) was shown to reduce tumor growth in several cancer models both in vitro and in vivo. So far only a few targets of TQ, including protein kinases have been identified. Considering that kinases are...
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Article
Open AccessCorticotropin-releasing hormone stimulates expression of leptin, 11beta-HSD2 and syncytin-1 in primary human trophoblasts
The placental syncytiotrophoblast is the major source of maternal plasma corticotropin-releasing hormone (CRH) in the second half of pregnancy. Placental CRH exerts multiple functions in the maternal organism:...
