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Article
Open AccessRNA sequencing reveals induction of specific renal inflammatory pathways in a rat model of malignant hypertension
In malignant hypertension, far more severe kidney injury occurs than in the “benign” form of the disease. The role of high blood pressure and the renin–angiotensin–aldosterone system is well recognized, but th...
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Article
Open AccessPrevalence of metastases within the hypothalamic-pituitary area in patients with brain metastases
To quantify the prevalence of brain metastases involving the hypothalamic-pituitary (HT-P) area.
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Article
Open AccessSex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8
Apoe-deficient (Apoe −/−) mice develop progressive atherosclerotic lesions with age but no severe renal pathology in the absence of additional challenges. We...
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Article
Trophoblast expression dynamics of the tumor suppressor gene gastrokine 2
Gastrokines (GKNs) were originally described as stomach-specific tumor suppressor genes. Recently, we identified GKN1 in extravillous trophoblasts (EVT) of human placenta. GKN1 treatment reduced the migration ...
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Article
Open AccessThymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer
Thymoquinone (TQ) was shown to reduce tumor growth in several cancer models both in vitro and in vivo. So far only a few targets of TQ, including protein kinases have been identified. Considering that kinases are...