-
Article
Imaging apoptosis in the eye
Apoptosis is a form of programmed cell death that is implicated in both pathological and physiological processes throughout the body. Its imaging in vivo with intravenous radiolabelled-annexin V has been heralded...
-
Article
In-vivo-Imaging retinaler Zellapoptose nach akuter Lichtexposition
Bisher war der Nachweis von retinaler Apoptose in der äußeren Körnerschicht nach akuter Lichtexposition auf histologische Untersuchungen [12] beschränkt. In dieser Studie untersuchen wir, ob programmierter Zellto...
-
Article
Open AccessImaging multiple phases of neurodegeneration: a novel approach to assessing cell death in vivo
Nerve cell death is the key event in all neurodegenerative disorders, with apoptosis and necrosis being central to both acute and chronic degenerative processes. However, until now, it has not been possible to...
-
Article
Pointwise linear progression criteria and the detection of visual field change in a glaucoma trial
Current pointwise linear regression (PLR) change criteria for visual field analysis are largely empirical.
-
Article
Improving on ETDRS acuities: design and results for a computerised thresholding device
Aims All visual acuity data are subject to test–retest variability (TRV). This measurement error obscures true clinical change and reduces the statistical power of clinical trials using acuity as a primary outcom...
-
Article
Symptomatic abnormalities of dark adaptation in patients with EFEMP1 retinal dystrophy (Malattia Leventinese/Doyne honeycomb retinal dystrophy)
Purpose To investigate the nature of symptomatic visual disturbance in patients with EFEMP1 retinal dystrophy in the absence of geographic atrophy or choroidal neovascularization.
-
Article
Functional assessment of the native retinal pigment epithelium after the surgical excision of subfoveal choroidal neovascular membranes type II: preliminary results
-
Chapter
Functional assessment of the native retinal pigment epithelium after the surgical excision of subfoveal choroidal neovascular membranes type II: prelimianry results
Subretinal neovascular membranes (CNV) can occur in a variety of conditions. SRNVM most commonly occur in age-related macular degeneration (AMD), punctate inner choroidopathy (PIC)/multifocal inner choroidopat...
-
Article
Imaging the optic nerve and ganglion cell layer
New imaging techniques have extended the limitations of visualisation of the structures of the optic nerve and fundus in the living human eye. Quantitative reconstruction of depth of the optic nerve head is be...
-
Article
Electrophysiological findings in Dominant Optic Atrophy (DOA) linking to the OPA1 locus on chromosome 3q 28-qter
Pattern and flash visual evoked cortical potentials (PVEP, FVEP), and pattern electroretinograms, (PERG) were recorded in 13 affected individuals from 8 families with DOA. These were selected as representative...
-
Chapter
Functional and Imaging Investigations in Patients with Well-Defined Abnormalities of the Visual System
Enoch has led and inspired a school of research activity which aims to further our understanding of the visual consequences of specific and well characterized abnormalities of the visual system. For example, u...
-
Article
Modelling series of visual fields to detect progression in normal-tension glaucoma
• Background: Use of statistical modelling techniques to identify models that both describe glaucomatous sensitivity decay and allow predictions of future field status. • Method: Twelve initially normal fellow...
-
Article
Corneal topography: A new photokeratoscope
The assessment of the topography of the cornea is an important modality in the management of surgical procedures complicated by astigmatism. Additionally, the outcome of corneal refractive surgery is often bes...
-
Article
Probing visual function with psychophysics and photochemistry
New methods using computer based measurements and image analysis techniques can improve and expand our ability to investigate non-invasively the function of the retina in patients. These can provide insight in...
-
Article
Sorsby's pseudoinflammatory macula dystrophy—Sorsby's fundus dystrophies
The findings are presented on the updated Kempster pedigree with Sorsby's fundus dystrophy. The study confirms the features described in other families: autosomal dominant inheritance with complete penetrance,...
-
Article
Clinical psychophysics
New developments in clinical psychophysics allow a non-invasive assessment of visual function which may otherwise not be possible. Measurements of spatial and temporal contrast sensitivity functions, perimetri...
-
Article
Myopia: Induced, normal and clinical
A review is given of lid-suture myopia in monkeys, of the natural lower field myopia in the pigeon eye, and of myopias in chick eyes produced by visual occluders. The ametropias produced by ophthalmic lenses, ...
-
Chapter
Peripheral displacement thresholds in normals, ocular hypertensives and glaucoma
Displacement thresholds may depend on processing by ganglion cells and, like contrast sensitivity and colour vision, may therefore be affected in glaucoma. However, unlike contrast sensitivity and colour visio...
-
Article
Retinal dysfunction in central serous retinopathy
Patients with acute and chronic central serous retinopathy (CSR) were studied by psychophysical and photochemical means to establish the extent of visual depression and to investigate the basis of rod dysfunct...
